› 8sxj

Electron Microscopy
4Å resolution

CH505 Disulfide Stapled SOSIP Bound to CH235.12 Fab

Released:
DOI: 10.2210/pdb8sxj/pdb
PDB entry 8sxj coloured by chain, front view.
PDB entry 8sxj coloured by chain, side view.
PDB entry 8sxj coloured by chain, top view.
Source organisms:
Primary publication:
Microsecond dynamics control the HIV-1 Envelope conformation.
Bennett AL, Edwards R, Kosheleva I, Saunders C, Bililign Y, Williams A, Bubphamala P, Manosouri K, Anasti K, Saunders KO, Alam SM, Haynes BF, Acharya P, Henderson R
Sci Adv 10 eadj0396 (2024)
PMID: 38306419
Related structures: EMD-40854

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:

Structure analysis Details

Assembly composition:
hetero dodecamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-239896 (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (4 distinct):
Envelope glycoprotein gp160 Chains: A, E, I
Molecule details ›
Chains: A, E, I
Length: 456 amino acids
Theoretical weight: 51.45 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Homo sapiens
UniProt:
  • Canonical: M4M3Q1 (Residues: 31-483; Coverage: 54%)
Gene name: env
Sequence domains: Envelope glycoprotein GP120
HIV-1 gp41 Chains: B, F, J
Molecule details ›
Chains: B, F, J
Length: 126 amino acids
Theoretical weight: 14.27 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Homo sapiens
CH235.12 Heavy Chain Chains: C, G, K
Molecule details ›
Chains: C, G, K
Length: 122 amino acids
Theoretical weight: 13.72 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
CH235.12 Light Chain Chains: D, H, L
Molecule details ›
Chains: D, H, L
Length: 105 amino acids
Theoretical weight: 11.56 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 4Å
Relevant EMDB volumes: EMD-40854
Expression system: Homo sapiens

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