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CH505 Disulfide Stapled SOSIP Bound to CH235.12 Fab

Electron Microscopy
4Å resolution
PDB entry 8sxj coloured by chain, front view.
PDB entry 8sxj coloured by chain, side view.
PDB entry 8sxj coloured by chain, top view.
Source organisms:
Assembly composition:
hetero dodecamer (preferred)
Entry contents: 4 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Envelope glycoprotein gp160 and IG-heavy chain and IG-light kappa chain
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Multimeric state: hetero dodecamer
Accessible surface area: 102180.98 Å2
Buried surface area: 37627.11 Å2
Dissociation area: 4,197.16 Å2
Dissociation energy (ΔGdiss): 4.38 kcal/mol
Dissociation entropy (TΔSdiss): 42 kcal/mol
Symmetry number: 3
PDBe Complex ID: PDB-CPX-239896

Macromolecules

Envelope glycoprotein gp160
Chains: A, E, I
Length: 456 amino acids
Theoretical weight: 51.45 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Homo sapiens
UniProt:
  • Canonical: M4M3Q1 (Residues: 31-483; Coverage: 54%)
Gene name: env
Pfam: Envelope glycoprotein GP120
Envelope glycoprotein gp160 in PDB entry 8sxj, assembly 1, front view.
Envelope glycoprotein gp160 in PDB entry 8sxj, assembly 1, side view.
Envelope glycoprotein gp160 in PDB entry 8sxj, assembly 1, top view.
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HIV-1 gp41
Chains: B, F, J
Length: 126 amino acids
Theoretical weight: 14.27 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Homo sapiens
HIV-1 gp41 in PDB entry 8sxj, assembly 1, front view.
HIV-1 gp41 in PDB entry 8sxj, assembly 1, side view.
HIV-1 gp41 in PDB entry 8sxj, assembly 1, top view.
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CH235.12 Heavy Chain
Chains: C, G, K
Length: 122 amino acids
Theoretical weight: 13.72 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
CH235.12 Heavy Chain in PDB entry 8sxj, assembly 1, front view.
CH235.12 Heavy Chain in PDB entry 8sxj, assembly 1, side view.
CH235.12 Heavy Chain in PDB entry 8sxj, assembly 1, top view.
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CH235.12 Light Chain
Chains: D, H, L
Length: 105 amino acids
Theoretical weight: 11.56 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
CH235.12 Light Chain in PDB entry 8sxj, assembly 1, front view.
CH235.12 Light Chain in PDB entry 8sxj, assembly 1, side view.
CH235.12 Light Chain in PDB entry 8sxj, assembly 1, top view.
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