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Human VPS35L/VPS29/VPS26C Complex

Electron Microscopy
2.94Å resolution
PDB entry 8syn coloured by chain, front view.
PDB entry 8syn coloured by chain, side view.
PDB entry 8syn coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero trimer (preferred)
Entry contents: 3 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero trimer
Accessible surface area: 56424.18 Å2
Buried surface area: 6998.97 Å2
Dissociation area: 1,017.3 Å2
Dissociation energy (ΔGdiss): 1.74 kcal/mol
Dissociation entropy (TΔSdiss): 14.18 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-233859

Macromolecules

VPS35 endosomal protein-sorting factor-like
Chain: A
Length: 963 amino acids
Theoretical weight: 109.7 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q7Z3J2 (Residues: 1-963; Coverage: 100%)
Gene names: 101F10.2, C16orf62, VPS35L
VPS35 endosomal protein-sorting factor-like in PDB entry 8syn, assembly 1, front view.
VPS35 endosomal protein-sorting factor-like in PDB entry 8syn, assembly 1, side view.
VPS35 endosomal protein-sorting factor-like in PDB entry 8syn, assembly 1, top view.
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Vacuolar protein sorting-associated protein 29
Chain: B
Length: 205 amino acids
Theoretical weight: 23.04 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q9UBQ0 (Residues: 2-182; Coverage: 100%)
Gene names: DC15, DC7, MDS007, VPS29
Pfam: Calcineurin-like phosphoesterase superfamily domain
Vacuolar protein sorting-associated protein 29 in PDB entry 8syn, assembly 1, front view.
Vacuolar protein sorting-associated protein 29 in PDB entry 8syn, assembly 1, side view.
Vacuolar protein sorting-associated protein 29 in PDB entry 8syn, assembly 1, top view.
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Vacuolar protein sorting-associated protein 26C
Chain: C
Length: 297 amino acids
Theoretical weight: 33.05 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: O14972 (Residues: 1-297; Coverage: 100%)
Gene names: DCRA, DSCR3, DSCRA, VPS26C
Pfam: Vacuolar protein sorting-associated protein 26
Vacuolar protein sorting-associated protein 26C in PDB entry 8syn, assembly 1, front view.
Vacuolar protein sorting-associated protein 26C in PDB entry 8syn, assembly 1, side view.
Vacuolar protein sorting-associated protein 26C in PDB entry 8syn, assembly 1, top view.
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