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Cryo-EM structure of cinacalcet-bound active-state human calcium-sensing receptor CaSR in lipid nanodiscs

Source organism: Homo sapiens
Biochemical function: G protein-coupled receptor activity
Biological process: G protein-coupled receptor signaling pathway
Cellular component: membrane

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GO terms

Biochemical function:
Biological process:
Cellular component:

Sequence families

Pfam Protein families (Pfam)
PF00003
Domain description: 7 transmembrane sweet-taste receptor of 3 GCPR
Occurring in:
  1. Extracellular calcium-sensing receptor
  2. Extracellular calcium-sensing receptor
The deposited structure of PDB entry 8szf contains 1 copy of Pfam domain PF00003 (7 transmembrane sweet-taste receptor of 3 GCPR) in Extracellular calcium-sensing receptor. Showing 1 copy in chain A.
The deposited structure of PDB entry 8szf contains 1 copy of Pfam domain PF00003 (7 transmembrane sweet-taste receptor of 3 GCPR) in Extracellular calcium-sensing receptor. Showing 1 copy in chain B.

PF07562
Domain description: Nine Cysteines Domain of family 3 GPCR
Occurring in:
  1. Extracellular calcium-sensing receptor
  2. Extracellular calcium-sensing receptor
The deposited structure of PDB entry 8szf contains 1 copy of Pfam domain PF07562 (Nine Cysteines Domain of family 3 GPCR) in Extracellular calcium-sensing receptor. Showing 1 copy in chain A.
The deposited structure of PDB entry 8szf contains 1 copy of Pfam domain PF07562 (Nine Cysteines Domain of family 3 GPCR) in Extracellular calcium-sensing receptor. Showing 1 copy in chain B.

PF01094
Domain description: Receptor family ligand binding region
Occurring in:
  1. Extracellular calcium-sensing receptor
  2. Extracellular calcium-sensing receptor
The deposited structure of PDB entry 8szf contains 1 copy of Pfam domain PF01094 (Receptor family ligand binding region) in Extracellular calcium-sensing receptor. Showing 1 copy in chain A.
The deposited structure of PDB entry 8szf contains 1 copy of Pfam domain PF01094 (Receptor family ligand binding region) in Extracellular calcium-sensing receptor. Showing 1 copy in chain B.

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