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Cryo-EM structure of the RBD-ACE2 interface of the SARS-CoV-2 trimeric spike protein bound to ACE2 receptor after local refinement at upRBD conformation

Electron Microscopy
3.87Å resolution
PDB entry 8t23 coloured by chain, front view.
PDB entry 8t23 coloured by chain, side view.
PDB entry 8t23 coloured by chain, top view.
Source organisms:
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Spike protein S2' and Angiotensin-converting enzyme
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Multimeric state: hetero dimer
Accessible surface area: 51256.81 Å2
Buried surface area: 2306.59 Å2
Dissociation area: 619.34 Å2
Dissociation energy (ΔGdiss): -6 kcal/mol
Dissociation entropy (TΔSdiss): 13.2 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-269579

Macromolecules

Angiotensin-converting enzyme
Chain: A
Length: 771 amino acids
Theoretical weight: 89.38 KDa
Source organism: Neogale vison
Expression system: Homo sapiens
UniProt:
  • Canonical: A0A7T0Q2W2 (Residues: 1-739; Coverage: 92%)
Pfam:
Angiotensin-converting enzyme in PDB entry 8t23, assembly 1, front view.
Angiotensin-converting enzyme in PDB entry 8t23, assembly 1, side view.
Angiotensin-converting enzyme in PDB entry 8t23, assembly 1, top view.
PDBe-KB: UniProt Coverage View: A0A7T0Q2W2  
1771100200300400500600700
 
200400600
UniProt
A0A7T0Q2W2
Chains
Secondary structure
Ligand binding sites
Interaction interfaces
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Spike protein S1
Chain: B
Length: 208 amino acids
Theoretical weight: 23.37 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P0DTC2 (Residues: 321-528; Coverage: 17%)
Gene names: 2, S
Pfam: Betacoronavirus spike glycoprotein S1, receptor binding
Spike protein S1 in PDB entry 8t23, assembly 1, front view.
Spike protein S1 in PDB entry 8t23, assembly 1, side view.
Spike protein S1 in PDB entry 8t23, assembly 1, top view.
PDBe-KB: UniProt Coverage View: P0DTC2  
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