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Model of TTLL6 MTBH1-2 bound to microtubule

Electron Microscopy
3.6Å resolution
PDB entry 8t42 coloured by chain, front view.
PDB entry 8t42 coloured by chain, side view.
PDB entry 8t42 coloured by chain, top view.
Source organisms:
Assembly composition:
hetero pentamer (preferred)
Entry contents: 3 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero pentamer
Accessible surface area: 59817.57 Å2
Buried surface area: 16214.86 Å2
Dissociation area: 663.23 Å2
Dissociation energy (ΔGdiss): -2.75 kcal/mol
Dissociation entropy (TΔSdiss): 9.54 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-243986

Macromolecules

Tubulin alpha-1B chain
Chains: A, F
Length: 451 amino acids
Theoretical weight: 50.2 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P68363 (Residues: 1-451; Coverage: 100%)
Gene name: TUBA1B
Pfam:
Tubulin alpha-1B chain in PDB entry 8t42, assembly 1, front view.
Tubulin alpha-1B chain in PDB entry 8t42, assembly 1, side view.
Tubulin alpha-1B chain in PDB entry 8t42, assembly 1, top view.
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Tubulin beta chain
Chains: B, E
Length: 444 amino acids
Theoretical weight: 49.72 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P07437 (Residues: 1-444; Coverage: 100%)
Gene names: OK/SW-cl.56, TUBB, TUBB5
Pfam:
Tubulin beta chain in PDB entry 8t42, assembly 1, front view.
Tubulin beta chain in PDB entry 8t42, assembly 1, side view.
Tubulin beta chain in PDB entry 8t42, assembly 1, top view.
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Tubulin polyglutamylase TTLL6
Chain: N
Length: 503 amino acids
Theoretical weight: 59.15 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: A4Q9E8 (Residues: 1-503; Coverage: 61%)
Gene name: Ttll6
Pfam: Tubulin-tyrosine ligase family
Tubulin polyglutamylase TTLL6 in PDB entry 8t42, assembly 1, front view.
Tubulin polyglutamylase TTLL6 in PDB entry 8t42, assembly 1, side view.
Tubulin polyglutamylase TTLL6 in PDB entry 8t42, assembly 1, top view.
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