Function and Biology Details
Reactions catalysed:
ATP + H(2)O + antigen peptide(Side 1) = ADP + phosphate + antigen peptide(Side 2)
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1)
3'-end directed exonucleolytic cleavage of viral RNA-DNA hybrid
Endohydrolysis of RNA in RNA/DNA hybrids. Three different cleavage modes: 1. sequence-specific internal cleavage of RNA. Human immunodeficiency virus type 1 and Moloney murine leukemia virus enzymes prefer to cleave the RNA strand one nucleotide away from the RNA-DNA junction. 2. RNA 5'-end directed cleavage 13-19 nucleotides from the RNA end. 3. DNA 3'-end directed cleavage 15-20 nucleotides away from the primer terminus.
Specific for a P1 residue that is hydrophobic, and P1' variable, but often Pro.
Biochemical function:
- not assigned
Biological process:
- not assigned
Cellular component:
- not assigned
Structure analysis Details
Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-246021 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Antigen peptide transporter 1
Molecule details ›
Antigen peptide transporter 2
Molecule details ›
p51 RT
Molecule details ›
Chain: C
Length: 9 amino acids
Theoretical weight: 993 Da
Source organism: Human immunodeficiency virus 1
Expression system: Not provided
UniProt:
Length: 9 amino acids
Theoretical weight: 993 Da
Source organism: Human immunodeficiency virus 1
Expression system: Not provided
UniProt:
- Canonical:
P04588 (Residues: 901-909; Coverage: 1%)
