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Transporter associated with antigen processing (TAP) bound to the 9-mer peptide ILKEPVHGV

Electron Microscopy
3.5Å resolution
PDB entry 8t4e coloured by chain, front view.
PDB entry 8t4e coloured by chain, side view.
PDB entry 8t4e coloured by chain, top view.
Source organisms:
Assembly composition:
hetero trimer (preferred)
Entry contents: 3 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero trimer
Accessible surface area: 52621.48 Å2
Buried surface area: 10204.48 Å2
Dissociation area: 744.68 Å2
Dissociation energy (ΔGdiss): 4.85 kcal/mol
Dissociation entropy (TΔSdiss): 7.17 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-246021

Macromolecules

Antigen peptide transporter 1
Chain: A
Length: 748 amino acids
Theoretical weight: 81.03 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q03518 (Residues: 1-748; Coverage: 100%)
Gene names: ABCB2, PSF1, RING4, TAP1, Y3
Pfam:
Antigen peptide transporter 1 in PDB entry 8t4e, assembly 1, front view.
Antigen peptide transporter 1 in PDB entry 8t4e, assembly 1, side view.
Antigen peptide transporter 1 in PDB entry 8t4e, assembly 1, top view.
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Antigen peptide transporter 2
Chain: B
Length: 686 amino acids
Theoretical weight: 75.74 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q03519 (Residues: 1-686; Coverage: 100%)
Gene names: ABCB3, PSF2, RING11, TAP2, Y1
Pfam:
Antigen peptide transporter 2 in PDB entry 8t4e, assembly 1, front view.
Antigen peptide transporter 2 in PDB entry 8t4e, assembly 1, side view.
Antigen peptide transporter 2 in PDB entry 8t4e, assembly 1, top view.
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p51 RT
Chain: C
Length: 9 amino acids
Theoretical weight: 993 Da
Source organism: Human immunodeficiency virus 1
Expression system: Not provided
UniProt:
  • Canonical: P04588 (Residues: 901-909; Coverage: 1%)
Gene name: gag-pol
p51 RT in PDB entry 8t4e, assembly 1, front view.
p51 RT in PDB entry 8t4e, assembly 1, side view.
p51 RT in PDB entry 8t4e, assembly 1, top view.
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