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Cryo-EM structure of RSV preF in complex with Fab 2.4K

Electron Microscopy
2.8Å resolution
PDB entry 8t7a coloured by chain, front view.
PDB entry 8t7a coloured by chain, side view.
PDB entry 8t7a coloured by chain, top view.
Source organisms:
Assembly composition:
hetero dodecamer (preferred)
Entry contents: 4 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Fusion glycoprotein F1 and IG-heavy chain and IG-light kappa chain
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Multimeric state: hetero dodecamer
Accessible surface area: 81099.83 Å2
Buried surface area: 44718.45 Å2
Dissociation area: 3,056.85 Å2
Dissociation energy (ΔGdiss): 9.65 kcal/mol
Dissociation entropy (TΔSdiss): 37.26 kcal/mol
Symmetry number: 3
PDBe Complex ID: PDB-CPX-235068

Macromolecules

Fusion glycoprotein F2
Chains: A, B, C
Length: 84 amino acids
Theoretical weight: 9.5 KDa
Source organism: Respiratory syncytial virus A2
Expression system: Homo sapiens
UniProt:
  • Canonical: P12568 (Residues: 26-109; Coverage: 15%)
Gene name: F
Fusion glycoprotein F2 in PDB entry 8t7a, assembly 1, front view.
Fusion glycoprotein F2 in PDB entry 8t7a, assembly 1, side view.
Fusion glycoprotein F2 in PDB entry 8t7a, assembly 1, top view.
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Fusion glycoprotein F1
Chains: a, b, c
Length: 436 amino acids
Theoretical weight: 48.3 KDa
Source organism: Respiratory syncytial virus A2
Expression system: Homo sapiens
UniProt:
  • Canonical: P12568 (Residues: 137-513; Coverage: 69%)
Gene name: F
Pfam: Fusion glycoprotein F0
Fusion glycoprotein F1 in PDB entry 8t7a, assembly 1, front view.
Fusion glycoprotein F1 in PDB entry 8t7a, assembly 1, side view.
Fusion glycoprotein F1 in PDB entry 8t7a, assembly 1, top view.
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2.4K Fab Heavy Chain
Chains: D, F, H
Length: 125 amino acids
Theoretical weight: 13.69 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
2.4K Fab Heavy Chain in PDB entry 8t7a, assembly 1, front view.
2.4K Fab Heavy Chain in PDB entry 8t7a, assembly 1, side view.
2.4K Fab Heavy Chain in PDB entry 8t7a, assembly 1, top view.
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2.4K Fab Light Chain
Chains: E, G, I
Length: 113 amino acids
Theoretical weight: 12.45 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
2.4K Fab Light Chain in PDB entry 8t7a, assembly 1, front view.
2.4K Fab Light Chain in PDB entry 8t7a, assembly 1, side view.
2.4K Fab Light Chain in PDB entry 8t7a, assembly 1, top view.
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