PDB 8t7q biological assemblies and structure analysis ‹ Protein Data Bank in Europe (PDBe)

Assemblies

Assembly 1 (preferred)

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Assembly Name: Tyrosine-protein phosphatase non-receptor type 11
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Multimeric state: monomeric

Accessible surface area: 21962.74 Å²

Buried surface area: 0.0 Å²

Dissociation area: 0 Å²

Dissociation energy (ΔG^diss): 0 kcal/mol

Dissociation entropy (TΔS^diss): 0 kcal/mol

Symmetry number: 1

PDBe Complex ID: PDB-CPX-170287

$Monomeric assembly 1 of PDB entry 8t7q coloured by chemically distinct molecules, front view. This structure contains: <ul class='image_legend_ul'><li class='image_legend_li'>1 copy of Tyrosine-protein phosphatase non-receptor type 11;</li> <li class='image_legend_li'>1 copy of 1-{3-[(2-chlorophenyl)sulfanyl]-1H-pyrazolo[3,4-b]pyrazin-6-yl}-4-methylpiperidin-4-amine;</li> <li class='image_legend_li'>1 copy of water.</li></ul>}$

$Monomeric assembly 1 of PDB entry 8t7q coloured by chemically distinct molecules, side view. This structure contains: <ul class='image_legend_ul'><li class='image_legend_li'>1 copy of Tyrosine-protein phosphatase non-receptor type 11;</li> <li class='image_legend_li'>1 copy of 1-{3-[(2-chlorophenyl)sulfanyl]-1H-pyrazolo[3,4-b]pyrazin-6-yl}-4-methylpiperidin-4-amine;</li> <li class='image_legend_li'>1 copy of water.</li></ul>}$

$Monomeric assembly 1 of PDB entry 8t7q coloured by chemically distinct molecules, top view. This structure contains: <ul class='image_legend_ul'><li class='image_legend_li'>1 copy of Tyrosine-protein phosphatase non-receptor type 11;</li> <li class='image_legend_li'>1 copy of 1-{3-[(2-chlorophenyl)sulfanyl]-1H-pyrazolo[3,4-b]pyrazin-6-yl}-4-methylpiperidin-4-amine;</li> <li class='image_legend_li'>1 copy of water.</li></ul>}$

Assembly 2

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Assembly Name: Tyrosine-protein phosphatase non-receptor type 11
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Multimeric state: monomeric

Accessible surface area: 21235.53 Å²

Buried surface area: 0.0 Å²

Dissociation area: 0 Å²

Dissociation energy (ΔG^diss): 0 kcal/mol

Dissociation entropy (TΔS^diss): 0 kcal/mol

Symmetry number: 1

PDBe Complex ID: PDB-CPX-170287

$Monomeric assembly 2 of PDB entry 8t7q coloured by chemically distinct molecules, front view. This structure contains: <ul class='image_legend_ul'><li class='image_legend_li'>1 copy of Tyrosine-protein phosphatase non-receptor type 11;</li> <li class='image_legend_li'>1 copy of 1-{3-[(2-chlorophenyl)sulfanyl]-1H-pyrazolo[3,4-b]pyrazin-6-yl}-4-methylpiperidin-4-amine;</li> <li class='image_legend_li'>1 copy of water.</li></ul>}$

$Monomeric assembly 2 of PDB entry 8t7q coloured by chemically distinct molecules, side view. This structure contains: <ul class='image_legend_ul'><li class='image_legend_li'>1 copy of Tyrosine-protein phosphatase non-receptor type 11;</li> <li class='image_legend_li'>1 copy of 1-{3-[(2-chlorophenyl)sulfanyl]-1H-pyrazolo[3,4-b]pyrazin-6-yl}-4-methylpiperidin-4-amine;</li> <li class='image_legend_li'>1 copy of water.</li></ul>}$

$Monomeric assembly 2 of PDB entry 8t7q coloured by chemically distinct molecules, top view. This structure contains: <ul class='image_legend_ul'><li class='image_legend_li'>1 copy of Tyrosine-protein phosphatase non-receptor type 11;</li> <li class='image_legend_li'>1 copy of 1-{3-[(2-chlorophenyl)sulfanyl]-1H-pyrazolo[3,4-b]pyrazin-6-yl}-4-methylpiperidin-4-amine;</li> <li class='image_legend_li'>1 copy of water.</li></ul>}$

	UniProt
	Chains
	Secondary structure
	Ligand binding sites

Protein Data Bank in Europe

Identification of GDC-1971 (RLY-1971), a SHP2 inhibitor designed for the treatment of solid tumors

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Assemblies

Assembly 1 (preferred)

Assembly 2

Macromolecules

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PDBe › 8t7q › Structure analysis

Identification of GDC-1971 (RLY-1971), a SHP2 inhibitor designed for the treatment of solid tumors

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Assemblies

Assembly 1 (preferred)

Assembly 2

Macromolecules

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8t7q › Structure analysis