› 8tkh

Electron Microscopy
3.5Å resolution

Human Type 3 IP3 Receptor - Labile Resting State 1 (+IP3/ATP)

Released:
DOI: 10.2210/pdb8tkh/pdb
PDB entry 8tkh coloured by chain, front view.
PDB entry 8tkh coloured by chain, side view.
PDB entry 8tkh coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural titration reveals Ca2+-dependent conformational landscape of the IP3 receptor.
Paknejad N, Sapuru V, Hite RK
Nat Commun 14 6897 (2023)
PMID: 37898605
Related structures: EMD-41351

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172038 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Inositol 1,4,5-trisphosphate-gated calcium channel ITPR3 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 2671 amino acids
Theoretical weight: 304.49 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q14573 (Residues: 1-2671; Coverage: 100%)
Gene name: ITPR3
Sequence domains:

Ligands and Environments

3 bound ligands:
Ligand ZN 4 x ZN
Ligand I3P 4 x I3P
Ligand ATP 4 x ATP
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.5Å
Relevant EMDB volumes: EMD-41351
Expression system: Homo sapiens

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