› 8tp6

Electron Microscopy
3.1Å resolution

H2 hemagglutinin (A/Singapore/1/1957) in complex with RBS-targeting Fab 4-1-1E02

Released:
DOI: 10.2210/pdb8tp6/pdb
PDB entry 8tp6 coloured by chain, front view.
PDB entry 8tp6 coloured by chain, side view.
PDB entry 8tp6 coloured by chain, top view.
Source organisms:
Primary publication:
Immune memory shapes human polyclonal antibody responses to H2N2 vaccination.
Yang YR, Han J, Perrett HR, Richey ST, Jackson AM, Rodriguez AJ, Gillespie RA, O'Connell S, Raab JE, Cominsky LY, Chopde A, Kanekiyo M, Houser KV, Chen GL, McDermott AB, Andrews SF, Ward AB
bioRxiv (2023)
PMID: 37781590
Related structures: EMD-41468

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero nonamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-240926 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (5 distinct):
Hemagglutinin Chains: A, B, E
Molecule details ›
Chains: A, B, E
Length: 504 amino acids
Theoretical weight: 56.92 KDa
Source organism: Influenza A virus (A/Singapore/1/1957(H2N2))
Expression system: Homo sapiens
UniProt:
  • Canonical: Q67333 (Residues: 1-504; Coverage: 89%)
Gene name: HA
Sequence domains: Haemagglutinin
Heavy chain of 4-1-1E02 Fab Chains: C, F, H
Molecule details ›
Chains: C, F, H
Length: 122 amino acids
Theoretical weight: 13.17 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Light chain of 4-1-1E02 Fab Chains: D, G, L
Molecule details ›
Chains: D, G, L
Length: 107 amino acids
Theoretical weight: 11.69 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA, FUC
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
1 bound ligand:
Ligand NAG 9 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.1Å
Relevant EMDB volumes: EMD-41468
Expression system: Homo sapiens

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