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H2 hemagglutinin (A/Singapore/1/1957) in complex with RBS-targeting Fab 4-1-1E02

Electron Microscopy
3.1Å resolution
PDB entry 8tp6 coloured by chain, front view.
PDB entry 8tp6 coloured by chain, side view.
PDB entry 8tp6 coloured by chain, top view.
Source organisms:
Assembly composition:
hetero nonamer (preferred)
Entry contents: 3 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Hemagglutinin and IG-heavy chain and IG-light kappa chain
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Multimeric state: hetero nonamer
Accessible surface area: 88489.64 Å2
Buried surface area: 28245.03 Å2
Dissociation area: 5,454.3 Å2
Dissociation energy (ΔGdiss): 8.91 kcal/mol
Dissociation entropy (TΔSdiss): 74.13 kcal/mol
Symmetry number: 3
PDBe Complex ID: PDB-CPX-240926

Macromolecules

Hemagglutinin
Chains: A, B, E
Length: 504 amino acids
Theoretical weight: 56.92 KDa
Source organism: Influenza A virus (A/Singapore/1/1957(H2N2))
Expression system: Homo sapiens
UniProt:
  • Canonical: Q67333 (Residues: 1-504; Coverage: 89%)
Gene name: HA
Pfam: Haemagglutinin
Hemagglutinin HA2 chain in PDB entry 8tp6, assembly 1, front view.
Hemagglutinin HA2 chain in PDB entry 8tp6, assembly 1, side view.
Hemagglutinin HA2 chain in PDB entry 8tp6, assembly 1, top view.
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Heavy chain of 4-1-1E02 Fab
Chains: C, F, H
Length: 122 amino acids
Theoretical weight: 13.17 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Heavy chain of 4-1-1E02 Fab in PDB entry 8tp6, assembly 1, front view.
Heavy chain of 4-1-1E02 Fab in PDB entry 8tp6, assembly 1, side view.
Heavy chain of 4-1-1E02 Fab in PDB entry 8tp6, assembly 1, top view.
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Light chain of 4-1-1E02 Fab
Chains: D, G, L
Length: 107 amino acids
Theoretical weight: 11.69 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Light chain of 4-1-1E02 Fab in PDB entry 8tp6, assembly 1, front view.
Light chain of 4-1-1E02 Fab in PDB entry 8tp6, assembly 1, side view.
Light chain of 4-1-1E02 Fab in PDB entry 8tp6, assembly 1, top view.
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