› 8tpa

Electron Microscopy
3Å resolution

H1 hemagglutinin (NC99) in complex with medial-junction-targeting Fab 2-2-1G06

Released:
DOI: 10.2210/pdb8tpa/pdb
PDB entry 8tpa coloured by chain, front view.
PDB entry 8tpa coloured by chain, side view.
PDB entry 8tpa coloured by chain, top view.
Source organisms:
Primary publication:
Immune memory shapes human polyclonal antibody responses to H2N2 vaccination.
Yang YR, Han J, Perrett HR, Richey ST, Jackson AM, Rodriguez AJ, Gillespie RA, O'Connell S, Raab JE, Cominsky LY, Chopde A, Kanekiyo M, Houser KV, Chen GL, McDermott AB, Andrews SF, Ward AB
OpenAccess logo bioRxiv (2023)
PMID: 37781590
Related structures: EMD-41471

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero dodecamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-232164 (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (5 distinct):
Hemagglutinin HA1 chain Chains: A, C, G
Molecule details ›
Chains: A, C, G
Length: 343 amino acids
Theoretical weight: 38.29 KDa
Source organism: Influenza A virus (A/New Caledonia/20/1999(H1N1))
Expression system: Homo sapiens
UniProt:
  • Canonical: Q6WG00 (Residues: 1-343; Coverage: 61%)
Gene name: HA
Sequence domains: Haemagglutinin
Heavy chain of Fab 2-2-1G06 Chains: D, H, I
Molecule details ›
Chains: D, H, I
Length: 126 amino acids
Theoretical weight: 14.02 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Light chain of Fab 2-2-1G06 Chains: E, J, L
Molecule details ›
Chains: E, J, L
Length: 107 amino acids
Theoretical weight: 11.78 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Hemagglutinin HA2 chain Chains: B, F, K
Molecule details ›
Chains: B, F, K
Length: 222 amino acids
Theoretical weight: 25.07 KDa
Source organism: Influenza A virus (A/New Caledonia/20/1999(H1N1))
Expression system: Homo sapiens
UniProt:
  • Canonical: Q6WG00 (Residues: 344-565; Coverage: 39%)
Gene name: HA
Sequence domains: Haemagglutinin

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
1 bound ligand:
Ligand NAG 12 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3Å
Relevant EMDB volumes: EMD-41471
Expression system: Homo sapiens

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