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H1 hemagglutinin (NC99) in complex with medial-junction-targeting Fab 2-2-1G06

Electron Microscopy
3Å resolution
PDB entry 8tpa coloured by chain, front view.
PDB entry 8tpa coloured by chain, side view.
PDB entry 8tpa coloured by chain, top view.
Source organisms:
Assembly composition:
hetero dodecamer (preferred)
Entry contents: 4 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Hemagglutinin HA1 chain and IG-heavy chain and IG-light kappa chain
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Multimeric state: hetero dodecamer
Accessible surface area: 89994.59 Å2
Buried surface area: 43437.09 Å2
Dissociation area: 4,919.85 Å2
Dissociation energy (ΔGdiss): 34.7 kcal/mol
Dissociation entropy (TΔSdiss): 38.61 kcal/mol
Symmetry number: 3
PDBe Complex ID: PDB-CPX-232164

Macromolecules

Hemagglutinin HA1 chain
Chains: A, C, G
Length: 343 amino acids
Theoretical weight: 38.29 KDa
Source organism: Influenza A virus (A/New Caledonia/20/1999(H1N1))
Expression system: Homo sapiens
UniProt:
  • Canonical: Q6WG00 (Residues: 1-343; Coverage: 61%)
Gene name: HA
Pfam: Haemagglutinin
Hemagglutinin HA1 chain in PDB entry 8tpa, assembly 1, front view.
Hemagglutinin HA1 chain in PDB entry 8tpa, assembly 1, side view.
Hemagglutinin HA1 chain in PDB entry 8tpa, assembly 1, top view.
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Heavy chain of Fab 2-2-1G06
Chains: D, H, I
Length: 126 amino acids
Theoretical weight: 14.02 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Heavy chain of Fab 2-2-1G06 in PDB entry 8tpa, assembly 1, front view.
Heavy chain of Fab 2-2-1G06 in PDB entry 8tpa, assembly 1, side view.
Heavy chain of Fab 2-2-1G06 in PDB entry 8tpa, assembly 1, top view.
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Light chain of Fab 2-2-1G06
Chains: E, J, L
Length: 107 amino acids
Theoretical weight: 11.78 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Light chain of Fab 2-2-1G06 in PDB entry 8tpa, assembly 1, front view.
Light chain of Fab 2-2-1G06 in PDB entry 8tpa, assembly 1, side view.
Light chain of Fab 2-2-1G06 in PDB entry 8tpa, assembly 1, top view.
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Hemagglutinin HA2 chain
Chains: B, F, K
Length: 222 amino acids
Theoretical weight: 25.07 KDa
Source organism: Influenza A virus (A/New Caledonia/20/1999(H1N1))
Expression system: Homo sapiens
UniProt:
  • Canonical: Q6WG00 (Residues: 344-565; Coverage: 39%)
Gene name: HA
Pfam: Haemagglutinin
Hemagglutinin HA2 chain in PDB entry 8tpa, assembly 1, front view.
Hemagglutinin HA2 chain in PDB entry 8tpa, assembly 1, side view.
Hemagglutinin HA2 chain in PDB entry 8tpa, assembly 1, top view.
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