8tqw

Electron Microscopy
8.2Å resolution

Structure of human transcriptional Mediator complex

Released:

Function and Biology Details

Reactions catalysed:
ATP + a protein = ADP + a phosphoprotein
ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero 29-mer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-252173 (preferred)
Entry contents:
29 distinct polypeptide molecules
Macromolecules (29 distinct):
Mediator of RNA polymerase II transcription subunit 27 Chain: 0
Molecule details ›
Chain: 0
Length: 311 amino acids
Theoretical weight: 35.48 KDa
Source organism: Homo sapiens
Mediator of RNA polymerase II transcription subunit 28 Chain: 1
Molecule details ›
Chain: 1
Length: 178 amino acids
Theoretical weight: 19.54 KDa
Source organism: Homo sapiens
Mediator of RNA polymerase II transcription subunit 29 Chain: 2
Mediator of RNA polymerase II transcription subunit 30 Chain: 3
Mediator of RNA polymerase II transcription subunit 31 Chain: 4
Mediator of RNA polymerase II transcription subunit 1 Chain: A
Unknown Chain Chain: B
Mediator of RNA polymerase II transcription subunit 4 Chain: D
Mediator of RNA polymerase II transcription subunit 6 Chain: F
Mediator of RNA polymerase II transcription subunit 7 Chain: G
Mediator of RNA polymerase II transcription subunit 8 Chain: H
Mediator of RNA polymerase II transcription subunit 9 Chain: I
Mediator of RNA polymerase II transcription subunit 10 Chain: J
Mediator of RNA polymerase II transcription subunit 11 Chain: K
Mediator of RNA polymerase II transcription subunit 14 Chain: N
Mediator of RNA polymerase II transcription subunit 15 Chain: O
Mediator of RNA polymerase II transcription subunit 16 Chain: P
Mediator of RNA polymerase II transcription subunit 17 Chain: Q
Mediator of RNA polymerase II transcription subunit 18 Chain: R
Mediator of RNA polymerase II transcription subunit 19 Chain: S
Mediator of RNA polymerase II transcription subunit 20 Chain: T
Mediator of RNA polymerase II transcription subunit 21 Chain: U
Mediator of RNA polymerase II transcription subunit 22 Chain: V
Mediator of RNA polymerase II transcription subunit 23 Chain: W
Mediator of RNA polymerase II transcription subunit 24 Chain: X
Cyclin-dependent kinase 8 Chain: a
Cyclin-C Chain: b
Mediator of RNA polymerase II transcription subunit 12 Chain: c
Mediator of RNA polymerase II transcription subunit 13 Chain: d

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 8.2Å
Relevant EMDB volumes: EMD-41565