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Structure of human transcriptional Mediator complex

Source organism: Homo sapiens
Biochemical function: protein binding
Biological process: positive regulation of transcription initiation by RNA polymerase II
Cellular component: nucleoplasm

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EC 2.7.11.23: [RNA-polymerase]-subunit kinase

Reaction catalysed:
ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate
Systematic name:
ATP:[DNA-directed RNA polymerase] phosphotransferase
Alternative Name(s):
  • CTD kinase
  • STK9

EC 2.7.11.22: Cyclin-dependent kinase

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein
Systematic name:
ATP:cyclin phosphotransferase
Alternative Name(s):
  • Bur1
  • Bur1 Cdk
  • CDK
  • Cak1
  • Cak1p
  • Cdc2
  • Cdc2 kinase
  • Cdc28p
  • Cdk-activating kinase
  • Cdk-activating protein kinase
  • Cdk1
  • Cdk2
  • Cdk2
  • Cdk3
  • Cdk4
  • Cdk5
  • Cdk6
  • Cdk7
  • Cdk8
  • Cdk9
  • Cyclin A-activated cdc2
  • Cyclin A-activated cdk2
  • Cyclin D-cdk6 kinase
  • Cyclin D-dependent kinase
  • Cyclin E kinase
  • Cyclin-A associated kinase
  • Cyclin-dependent kinase 6
  • Cyclin-dependent kinase-2
  • Cyclin-dependent kinase-4
  • Cyclin-dependent protein kinase activating kinase
  • Cyk
  • D-type cyclin kinase
  • Nclk
  • Neuronal cdc2-like kinase
  • PCTAIRE-1
  • STK25

GO terms

Sequence families

Pfam Protein families (Pfam)
PF06333
Domain description: Mediator complex subunit 13 C-terminal domain
Occurring in:
  1. Mediator of RNA polymerase II transcription subunit 13
The deposited structure of PDB entry 8tqw contains 1 copy of Pfam domain PF06333 (Mediator complex subunit 13 C-terminal domain) in Mediator of RNA polymerase II transcription subunit 13. Showing 1 copy in chain CA [auth d].

PF18296
Domain description: MID domain of medPIWI
Occurring in:
  1. Mediator of RNA polymerase II transcription subunit 13
The deposited structure of PDB entry 8tqw contains 1 copy of Pfam domain PF18296 (MID domain of medPIWI) in Mediator of RNA polymerase II transcription subunit 13. Showing 1 copy in chain CA [auth d].

PF12144
Domain description: Eukaryotic Mediator 12 catenin-binding domain
Occurring in:
  1. Mediator of RNA polymerase II transcription subunit 12
The deposited structure of PDB entry 8tqw contains 1 copy of Pfam domain PF12144 (Eukaryotic Mediator 12 catenin-binding domain) in Mediator of RNA polymerase II transcription subunit 12. Showing 1 copy in chain BA [auth c] (this domain is out of the observed residue ranges!).

PF12145
Domain description: Eukaryotic Mediator 12 subunit domain
Occurring in:
  1. Mediator of RNA polymerase II transcription subunit 12
The deposited structure of PDB entry 8tqw contains 1 copy of Pfam domain PF12145 (Eukaryotic Mediator 12 subunit domain) in Mediator of RNA polymerase II transcription subunit 12. Showing 1 copy in chain BA [auth c].

PF09497
Domain description: Transcription mediator complex subunit Med12
Occurring in:
  1. Mediator of RNA polymerase II transcription subunit 12
The deposited structure of PDB entry 8tqw contains 1 copy of Pfam domain PF09497 (Transcription mediator complex subunit Med12) in Mediator of RNA polymerase II transcription subunit 12. Showing 1 copy in chain BA [auth c].

PF16899
Domain description: Cyclin C-terminal domain
Occurring in:
  1. Cyclin-C
The deposited structure of PDB entry 8tqw contains 1 copy of Pfam domain PF16899 (Cyclin C-terminal domain) in Cyclin-C. Showing 1 copy in chain AA [auth b].

PF00134
Domain description: Cyclin, N-terminal domain
Occurring in:
  1. Cyclin-C
The deposited structure of PDB entry 8tqw contains 1 copy of Pfam domain PF00134 (Cyclin, N-terminal domain) in Cyclin-C. Showing 1 copy in chain AA [auth b].

PF00069
Domain description: Protein kinase domain
Occurring in:
  1. Cyclin-dependent kinase 8
The deposited structure of PDB entry 8tqw contains 1 copy of Pfam domain PF00069 (Protein kinase domain) in Cyclin-dependent kinase 8. Showing 1 copy in chain Z [auth a].

PF11277
Domain description: Mediator complex subunit 24 N-terminal
Occurring in:
  1. Mediator of RNA polymerase II transcription subunit 24
The deposited structure of PDB entry 8tqw contains 1 copy of Pfam domain PF11277 (Mediator complex subunit 24 N-terminal) in Mediator of RNA polymerase II transcription subunit 24. Showing 1 copy in chain Y [auth X].

PF11573
Domain description: Mediator complex subunit 23
Occurring in:
  1. Mediator of RNA polymerase II transcription subunit 23
The deposited structure of PDB entry 8tqw contains 1 copy of Pfam domain PF11573 (Mediator complex subunit 23) in Mediator of RNA polymerase II transcription subunit 23. Showing 1 copy in chain X [auth W].

PF06179
Domain description: Surfeit locus protein 5 subunit 22 of Mediator complex
Occurring in:
  1. Mediator of RNA polymerase II transcription subunit 22
The deposited structure of PDB entry 8tqw contains 1 copy of Pfam domain PF06179 (Surfeit locus protein 5 subunit 22 of Mediator complex) in Mediator of RNA polymerase II transcription subunit 22. Showing 1 copy in chain W [auth V].

PF11221
Domain description: Subunit 21 of Mediator complex
Occurring in:
  1. Mediator of RNA polymerase II transcription subunit 21
The deposited structure of PDB entry 8tqw contains 1 copy of Pfam domain PF11221 (Subunit 21 of Mediator complex) in Mediator of RNA polymerase II transcription subunit 21. Showing 1 copy in chain V [auth U].

PF08612
Domain description: TATA-binding related factor (TRF) of subunit 20 of Mediator complex
Occurring in:
  1. Mediator of RNA polymerase II transcription subunit 20
The deposited structure of PDB entry 8tqw contains 1 copy of Pfam domain PF08612 (TATA-binding related factor (TRF) of subunit 20 of Mediator complex) in Mediator of RNA polymerase II transcription subunit 20. Showing 1 copy in chain U [auth T].

PF10278
Domain description: Mediator of RNA pol II transcription subunit 19
Occurring in:
  1. Mediator of RNA polymerase II transcription subunit 19
The deposited structure of PDB entry 8tqw contains 1 copy of Pfam domain PF10278 (Mediator of RNA pol II transcription subunit 19 ) in Mediator of RNA polymerase II transcription subunit 19. Showing 1 copy in chain T [auth S].

PF09637
Domain description: Med18 protein
Occurring in:
  1. Mediator of RNA polymerase II transcription subunit 18
The deposited structure of PDB entry 8tqw contains 1 copy of Pfam domain PF09637 (Med18 protein) in Mediator of RNA polymerase II transcription subunit 18. Showing 1 copy in chain S [auth R].

PF10156
Domain description: Subunit 17 of Mediator complex
Occurring in:
  1. Mediator of RNA polymerase II transcription subunit 17
The deposited structure of PDB entry 8tqw contains 1 copy of Pfam domain PF10156 (Subunit 17 of Mediator complex) in Mediator of RNA polymerase II transcription subunit 17. Showing 1 copy in chain R [auth Q].

PF20719
Domain description: Mediator complex subunit 16, C-terminal
Occurring in:
  1. Mediator of RNA polymerase II transcription subunit 16
The deposited structure of PDB entry 8tqw contains 1 copy of Pfam domain PF20719 (Mediator complex subunit 16, C-terminal) in Mediator of RNA polymerase II transcription subunit 16. Showing 1 copy in chain Q [auth P].

PF20718
Domain description: Mediator complex subunit 16, central helical bridge
Occurring in:
  1. Mediator of RNA polymerase II transcription subunit 16
The deposited structure of PDB entry 8tqw contains 1 copy of Pfam domain PF20718 (Mediator complex subunit 16, central helical bridge) in Mediator of RNA polymerase II transcription subunit 16. Showing 1 copy in chain Q [auth P].

PF11635
Domain description: Mediator complex subunit 16, N-terminal
Occurring in:
  1. Mediator of RNA polymerase II transcription subunit 16
The deposited structure of PDB entry 8tqw contains 1 copy of Pfam domain PF11635 (Mediator complex subunit 16, N-terminal) in Mediator of RNA polymerase II transcription subunit 16. Showing 1 copy in chain Q [auth P].

PF00400
Domain description: WD domain, G-beta repeat
Occurring in:
  1. Mediator of RNA polymerase II transcription subunit 16
The deposited structure of PDB entry 8tqw contains 1 copy of Pfam domain PF00400 (WD domain, G-beta repeat) in Mediator of RNA polymerase II transcription subunit 16. Showing 1 copy in chain Q [auth P].

PF21539
Domain description: ARC105/Med15 mediator subunit C-terminal domain
Occurring in:
  1. Mediator of RNA polymerase II transcription subunit 15
The deposited structure of PDB entry 8tqw contains 1 copy of Pfam domain PF21539 (ARC105/Med15 mediator subunit C-terminal domain) in Mediator of RNA polymerase II transcription subunit 15. Showing 1 copy in chain P [auth O].

PF21538
Domain description: ARC105/Med15 mediator subunit central domain
Occurring in:
  1. Mediator of RNA polymerase II transcription subunit 15
The deposited structure of PDB entry 8tqw contains 1 copy of Pfam domain PF21538 (ARC105/Med15 mediator subunit central domain) in Mediator of RNA polymerase II transcription subunit 15. Showing 1 copy in chain P [auth O].

PF09606
Domain description: ARC105/Med15 mediator subunit N-terminal KIX domain
Occurring in:
  1. Mediator of RNA polymerase II transcription subunit 15
The deposited structure of PDB entry 8tqw contains 1 copy of Pfam domain PF09606 (ARC105/Med15 mediator subunit N-terminal KIX domain) in Mediator of RNA polymerase II transcription subunit 15. Showing 1 copy in chain P [auth O] (this domain is out of the observed residue ranges!).

PF22983
Domain description: Mediator of RNA polymerase II transcription subunit 14, RM8
Occurring in:
  1. Mediator of RNA polymerase II transcription subunit 14
The deposited structure of PDB entry 8tqw contains 1 copy of Pfam domain PF22983 (Mediator of RNA polymerase II transcription subunit 14, RM8) in Mediator of RNA polymerase II transcription subunit 14. Showing 1 copy in chain O [auth N].

PF22984
Domain description: Mediator of RNA polymerase II transcription subunit 14, RM6
Occurring in:
  1. Mediator of RNA polymerase II transcription subunit 14
The deposited structure of PDB entry 8tqw contains 1 copy of Pfam domain PF22984 (Mediator of RNA polymerase II transcription subunit 14, RM6) in Mediator of RNA polymerase II transcription subunit 14. Showing 1 copy in chain O [auth N].

PF22981
Domain description: Mediator of RNA polymerase II transcription subunit 14, RM2
Occurring in:
  1. Mediator of RNA polymerase II transcription subunit 14
The deposited structure of PDB entry 8tqw contains 1 copy of Pfam domain PF22981 (Mediator of RNA polymerase II transcription subunit 14, RM2) in Mediator of RNA polymerase II transcription subunit 14. Showing 1 copy in chain O [auth N].

PF08638
Domain description: Mediator complex subunit MED14
Occurring in:
  1. Mediator of RNA polymerase II transcription subunit 14
The deposited structure of PDB entry 8tqw contains 1 copy of Pfam domain PF08638 (Mediator complex subunit MED14) in Mediator of RNA polymerase II transcription subunit 14. Showing 1 copy in chain O [auth N].

PF10280
Domain description: Mediator complex protein
Occurring in:
  1. Mediator of RNA polymerase II transcription subunit 11
The deposited structure of PDB entry 8tqw contains 1 copy of Pfam domain PF10280 (Mediator complex protein ) in Mediator of RNA polymerase II transcription subunit 11. Showing 1 copy in chain N [auth K].

PF09748
Domain description: Transcription factor subunit Med10 of Mediator complex
Occurring in:
  1. Mediator of RNA polymerase II transcription subunit 10
The deposited structure of PDB entry 8tqw contains 1 copy of Pfam domain PF09748 (Transcription factor subunit Med10 of Mediator complex) in Mediator of RNA polymerase II transcription subunit 10. Showing 1 copy in chain M [auth J].

PF07544
Domain description: RNA polymerase II transcription mediator complex subunit 9
Occurring in:
  1. Mediator of RNA polymerase II transcription subunit 9
The deposited structure of PDB entry 8tqw contains 1 copy of Pfam domain PF07544 (RNA polymerase II transcription mediator complex subunit 9) in Mediator of RNA polymerase II transcription subunit 9. Showing 1 copy in chain L [auth I].

PF10232
Domain description: Mediator of RNA polymerase II transcription complex subunit 8
Occurring in:
  1. Mediator of RNA polymerase II transcription subunit 8
The deposited structure of PDB entry 8tqw contains 1 copy of Pfam domain PF10232 (Mediator of RNA polymerase II transcription complex subunit 8) in Mediator of RNA polymerase II transcription subunit 8. Showing 1 copy in chain K [auth H].

PF05983
Domain description: MED7 protein
Occurring in:
  1. Mediator of RNA polymerase II transcription subunit 7
The deposited structure of PDB entry 8tqw contains 1 copy of Pfam domain PF05983 (MED7 protein) in Mediator of RNA polymerase II transcription subunit 7. Showing 1 copy in chain J [auth G].

PF04934
Domain description: MED6 mediator sub complex component
Occurring in:
  1. Mediator of RNA polymerase II transcription subunit 6
The deposited structure of PDB entry 8tqw contains 1 copy of Pfam domain PF04934 (MED6 mediator sub complex component) in Mediator of RNA polymerase II transcription subunit 6. Showing 1 copy in chain I [auth F].

PF10018
Domain description: Vitamin-D-receptor interacting Mediator subunit 4
Occurring in:
  1. Mediator of RNA polymerase II transcription subunit 4
The deposited structure of PDB entry 8tqw contains 1 copy of Pfam domain PF10018 (Vitamin-D-receptor interacting Mediator subunit 4) in Mediator of RNA polymerase II transcription subunit 4. Showing 1 copy in chain H [auth D].

PF10744
Domain description: Mediator of RNA polymerase II transcription subunit 1
Occurring in:
  1. Mediator of RNA polymerase II transcription subunit 1
The deposited structure of PDB entry 8tqw contains 1 copy of Pfam domain PF10744 (Mediator of RNA polymerase II transcription subunit 1) in Mediator of RNA polymerase II transcription subunit 1. Showing 1 copy in chain F [auth A].

PF05669
Domain description: SOH1
Occurring in:
  1. Mediator of RNA polymerase II transcription subunit 31
The deposited structure of PDB entry 8tqw contains 1 copy of Pfam domain PF05669 (SOH1) in Mediator of RNA polymerase II transcription subunit 31. Showing 1 copy in chain E [auth 4].

PF11315
Domain description: Mediator complex subunit 30
Occurring in:
  1. Mediator of RNA polymerase II transcription subunit 30
The deposited structure of PDB entry 8tqw contains 1 copy of Pfam domain PF11315 (Mediator complex subunit 30) in Mediator of RNA polymerase II transcription subunit 30. Showing 1 copy in chain D [auth 3].

PF11568
Domain description: Mediator complex subunit 29
Occurring in:
  1. Mediator of RNA polymerase II transcription subunit 29
The deposited structure of PDB entry 8tqw contains 1 copy of Pfam domain PF11568 (Mediator complex subunit 29) in Mediator of RNA polymerase II transcription subunit 29. Showing 1 copy in chain C [auth 2].

PF11594
Domain description: Mediator complex subunit 28
Occurring in:
  1. Mediator of RNA polymerase II transcription subunit 28
The deposited structure of PDB entry 8tqw contains 1 copy of Pfam domain PF11594 (Mediator complex subunit 28) in Mediator of RNA polymerase II transcription subunit 28. Showing 1 copy in chain B [auth 1].

PF11571
Domain description: Mediator complex subunit 27
Occurring in:
  1. Mediator of RNA polymerase II transcription subunit 27
The deposited structure of PDB entry 8tqw contains 1 copy of Pfam domain PF11571 (Mediator complex subunit 27) in Mediator of RNA polymerase II transcription subunit 27. Showing 1 copy in chain A [auth 0].

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