Function and Biology Details
Reactions catalysed:
ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate
ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
Structure analysis Details
Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-151133 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
Molecule details ›
Chain: A
Length: 1084 amino acids
Theoretical weight: 126.3 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
Sequence domains:
Length: 1084 amino acids
Theoretical weight: 126.3 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
- Canonical:
P42336 (Residues: 2-1068; Coverage: 100%)
Sequence domains:
Phosphatidylinositol 3-kinase regulatory subunit alpha
Molecule details ›
Chain: B
Length: 724 amino acids
Theoretical weight: 83.71 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
Sequence domains:
Length: 724 amino acids
Theoretical weight: 83.71 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
- Canonical: P27986 (Residues: 1-724; Coverage: 100%)
Sequence domains:
