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CryoEM structure of PI3Kalpha

Electron Microscopy
3.12Å resolution
PDB entry 8tu6 coloured by chain, front view.
PDB entry 8tu6 coloured by chain, side view.
PDB entry 8tu6 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Phosphatidylinositol 3-kinase complex class IA, p110alpha/p85alpha
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Multimeric state: hetero dimer
Accessible surface area: 54947.01 Å2
Buried surface area: 5610.25 Å2
Dissociation area: 2,805.13 Å2
Dissociation energy (ΔGdiss): 12.22 kcal/mol
Dissociation entropy (TΔSdiss): 15.36 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-151133
Complex Portal ID: CPX-2384

Macromolecules

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
Chain: A
Length: 1084 amino acids
Theoretical weight: 126.3 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P42336 (Residues: 2-1068; Coverage: 100%)
Gene name: PIK3CA
Pfam:
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform in PDB entry 8tu6, assembly 1, front view.
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform in PDB entry 8tu6, assembly 1, side view.
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform in PDB entry 8tu6, assembly 1, top view.
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Phosphatidylinositol 3-kinase regulatory subunit alpha
Chain: B
Length: 724 amino acids
Theoretical weight: 83.71 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P27986 (Residues: 1-724; Coverage: 100%)
Gene names: GRB1, PIK3R1
Pfam:
Phosphatidylinositol 3-kinase regulatory subunit alpha in PDB entry 8tu6, assembly 1, front view.
Phosphatidylinositol 3-kinase regulatory subunit alpha in PDB entry 8tu6, assembly 1, side view.
Phosphatidylinositol 3-kinase regulatory subunit alpha in PDB entry 8tu6, assembly 1, top view.
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