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Crystal structure of Fab-Lirilumab bound to KIR2DL3

X-ray diffraction
2.75Å resolution
PDB entry 8tui coloured by chain, front view.
PDB entry 8tui coloured by chain, side view.
PDB entry 8tui coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero trimer (preferred)
Entry contents: 3 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Killer cell immunoglobulin-like receptor 2DL3 and IG-heavy chain and IG-light kappa chain
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Multimeric state: hetero trimer
Accessible surface area: 23971.14 Å2
Buried surface area: 7553.2 Å2
Dissociation area: 955.33 Å2
Dissociation energy (ΔGdiss): 5.16 kcal/mol
Dissociation entropy (TΔSdiss): 12 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-236283

Macromolecules

Lirilumab Fab Heavy Chain
Chain: H
Length: 265 amino acids
Theoretical weight: 27.79 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
Lirilumab Fab Heavy Chain in PDB entry 8tui, assembly 1, front view.
Lirilumab Fab Heavy Chain in PDB entry 8tui, assembly 1, side view.
Lirilumab Fab Heavy Chain in PDB entry 8tui, assembly 1, top view.
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Lirilumab Fab Light chain
Chain: L
Length: 214 amino acids
Theoretical weight: 23.55 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
Lirilumab Fab Light chain in PDB entry 8tui, assembly 1, front view.
Lirilumab Fab Light chain in PDB entry 8tui, assembly 1, side view.
Lirilumab Fab Light chain in PDB entry 8tui, assembly 1, top view.
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Killer cell immunoglobulin-like receptor 2DL3
Chain: A
Length: 257 amino acids
Theoretical weight: 28.19 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P43628 (Residues: 22-245; Coverage: 70%)
Gene names: CD158B2, KIR2DL3, KIRCL23, NKAT2
Pfam: Immunoglobulin domain
Killer cell immunoglobulin-like receptor 2DL3 in PDB entry 8tui, assembly 1, front view.
Killer cell immunoglobulin-like receptor 2DL3 in PDB entry 8tui, assembly 1, side view.
Killer cell immunoglobulin-like receptor 2DL3 in PDB entry 8tui, assembly 1, top view.
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