› 8tz7

Electron Microscopy
3Å resolution

Cryo-EM structure of bovine concentrative nucleoside transporter 3 in complex with Molnupiravir, condition 1, INT1-INT1-INT1 conformation

Released:
DOI: 10.2210/pdb8tz7/pdb
PDB entry 8tz7 coloured by chain, front view.
PDB entry 8tz7 coloured by chain, side view.
PDB entry 8tz7 coloured by chain, top view.
Source organism: Bos taurus
Primary publication:
Antiviral drug recognition and elevator-type transport motions of CNT3.
Wright NJ, Zhang F, Suo Y, Kong L, Yin Y, Fedor JG, Sharma K, Borgnia MJ, Im W, Lee SY
Nat Chem Biol (2024)
PMID: 38418906
Related structures: EMD-41736

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-241200 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Sodium/nucleoside cotransporter Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 715 amino acids
Theoretical weight: 79.38 KDa
Source organism: Bos taurus
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: F1MGR1 (Residues: 1-699; Coverage: 100%)
Gene name: SLC28A3
Sequence domains:

Ligands and Environments

2 bound ligands:
Ligand XMO 3 x XMO
Ligand LBN 3 x LBN
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3Å
Relevant EMDB volumes: EMD-41736
Expression system: Spodoptera frugiperda

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