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Cryo-EM structure of bovine concentrative nucleoside transporter 3 in complex with Molnupiravir, condition 1, INT1-INT1-INT1 conformation

Electron Microscopy
3Å resolution
PDB entry 8tz7 coloured by chain, front view.
PDB entry 8tz7 coloured by chain, side view.
PDB entry 8tz7 coloured by chain, top view.
Source organism: Bos taurus
Assembly composition:
homo trimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Sodium/nucleoside cotransporter
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Multimeric state: homo trimer
Accessible surface area: 72009.53 Å2
Buried surface area: 9184.42 Å2
Dissociation area: 4,592.21 Å2
Dissociation energy (ΔGdiss): 74.54 kcal/mol
Dissociation entropy (TΔSdiss): 31.14 kcal/mol
Symmetry number: 3
PDBe Complex ID: PDB-CPX-241200

Macromolecules

Sodium/nucleoside cotransporter
Chains: A, B, C
Length: 715 amino acids
Theoretical weight: 79.38 KDa
Source organism: Bos taurus
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: F1MGR1 (Residues: 1-699; Coverage: 100%)
Gene name: SLC28A3
Pfam:
Sodium/nucleoside cotransporter in PDB entry 8tz7, assembly 1, front view.
Sodium/nucleoside cotransporter in PDB entry 8tz7, assembly 1, side view.
Sodium/nucleoside cotransporter in PDB entry 8tz7, assembly 1, top view.
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