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Crystal Structure of Acetyl-coenzyme A synthetase from Leishmania infantum (CoA, AMP and potassium bound)

Source organism: Leishmania infantum
Biochemical function: ligase activity
Biological process: acetyl-CoA biosynthetic process from acetate
Cellular component: not assigned

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EC 6.2.1.1: Acetate--CoA ligase

Reaction catalysed:
ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA
Systematic name:
Acetate:CoA ligase (AMP-forming)
Alternative Name(s):
  • ACS
  • Acetate thiokinase
  • Acetic thiokinase
  • Acetyl CoA ligase
  • Acetyl CoA synthase
  • Acetyl activating enzyme
  • Acetyl coenzyme A synthetase
  • Acetyl-CoA synthase
  • Acetyl-CoA synthetase
  • Acetyl-activating enzyme
  • Acetyl-coenzyme A synthase
  • Acyl-activating enzyme
  • Short chain fatty acyl-CoA synthetase
  • Short-chain acyl-coenzyme A synthetase

GO terms

Sequence families

Pfam Protein families (Pfam)
PF13193
Domain description: AMP-binding enzyme C-terminal domain
Occurring in:
  1. Acetyl-coenzyme A synthetase
The deposited structure of PDB entry 8u2u contains 1 copy of Pfam domain PF13193 (AMP-binding enzyme C-terminal domain) in Acetyl-coenzyme A synthetase. Showing 1 copy in chain A.

PF00501
Domain description: AMP-binding enzyme
Occurring in:
  1. Acetyl-coenzyme A synthetase
The deposited structure of PDB entry 8u2u contains 1 copy of Pfam domain PF00501 (AMP-binding enzyme) in Acetyl-coenzyme A synthetase. Showing 1 copy in chain A.

PF16177
Domain description: Acetyl-coenzyme A synthetase N-terminus
Occurring in:
  1. Acetyl-coenzyme A synthetase
The deposited structure of PDB entry 8u2u contains 1 copy of Pfam domain PF16177 (Acetyl-coenzyme A synthetase N-terminus) in Acetyl-coenzyme A synthetase. Showing 1 copy in chain A.

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