› 8u4r

Electron Microscopy
3.1Å resolution

Structure of REGN7663-Fab bound CXCR4

Released:
DOI: 10.2210/pdb8u4r/pdb
PDB entry 8u4r coloured by chain, front view.
PDB entry 8u4r coloured by chain, side view.
PDB entry 8u4r coloured by chain, top view.
Source organisms:
Primary publication:
Structural insights into CXCR4 modulation and oligomerization
Saotome K, McGoldrick LL, Ho J, Ramlall T, Shah S, Moore MJ, Kim JH, Leidich R, Olson WC, Franklin MC
Biorxiv (2024)
Related structures: EMD-41892

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-245786 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
REGN7663 Fab light chain Chain: L
Molecule details ›
Chain: L
Length: 219 amino acids
Theoretical weight: 24.19 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
REGN7663 Fab heavy chain Chain: H
Molecule details ›
Chain: H
Length: 240 amino acids
Theoretical weight: 25.8 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
C-X-C chemokine receptor type 4; Green fluorescent protein Chain: R
Molecule details ›
Chain: R
Length: 632 amino acids
Theoretical weight: 71.06 KDa
Source organisms: Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P61073 (Residues: 2-352; Coverage: 100%)
  • Canonical: P42212 (Residues: 1-238; Coverage: 100%)
Gene names: CXCR4, GFP
Sequence domains:

Ligands and Environments

1 bound ligand:
Ligand CLR 1 x CLR
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.1Å
Relevant EMDB volumes: EMD-41892
Expression systems:
  • Cricetulus griseus
  • Spodoptera frugiperda

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