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Structure of REGN7663-Fab bound CXCR4

Electron Microscopy
3.1Å resolution
PDB entry 8u4r coloured by chain, front view.
PDB entry 8u4r coloured by chain, side view.
PDB entry 8u4r coloured by chain, top view.
Source organisms:
Assembly composition:
hetero trimer (preferred)
Entry contents: 3 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: C-X-C chemokine receptor type 4, Green fluorescent protein and IG-light kappa chain and IG-heavy chain
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Multimeric state: hetero trimer
Accessible surface area: 23900.88 Å2
Buried surface area: 5240.8 Å2
Dissociation area: 1,505.63 Å2
Dissociation energy (ΔGdiss): 3.35 kcal/mol
Dissociation entropy (TΔSdiss): 12.9 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-245786

Macromolecules

REGN7663 Fab light chain
Chain: L
Length: 219 amino acids
Theoretical weight: 24.19 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
REGN7663 Fab light chain in PDB entry 8u4r, assembly 1, front view.
REGN7663 Fab light chain in PDB entry 8u4r, assembly 1, side view.
REGN7663 Fab light chain in PDB entry 8u4r, assembly 1, top view.
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REGN7663 Fab heavy chain
Chain: H
Length: 240 amino acids
Theoretical weight: 25.8 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
REGN7663 Fab heavy chain in PDB entry 8u4r, assembly 1, front view.
REGN7663 Fab heavy chain in PDB entry 8u4r, assembly 1, side view.
REGN7663 Fab heavy chain in PDB entry 8u4r, assembly 1, top view.
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C-X-C chemokine receptor type 4; Green fluorescent protein
Chain: R
Length: 632 amino acids
Theoretical weight: 71.06 KDa
Source organisms: Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P61073 (Residues: 2-352; Coverage: 100%)
  • Canonical: P42212 (Residues: 1-238; Coverage: 100%)
    • nullnull
Gene names: CXCR4, GFP
Pfam:
C-X-C chemokine receptor type 4 in PDB entry 8u4r, assembly 1, front view.
C-X-C chemokine receptor type 4 in PDB entry 8u4r, assembly 1, side view.
C-X-C chemokine receptor type 4 in PDB entry 8u4r, assembly 1, top view.
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