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KCTD5/Cullin3/Gbeta1gamma2 Complex: State C From Composite RELION Multi-body Refinement Map

Electron Microscopy
3.975Å resolution
PDB entry 8u83 coloured by chain, front view.
PDB entry 8u83 coloured by chain, side view.
PDB entry 8u83 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero icosamer (preferred)
Entry contents: 4 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero icosamer
Accessible surface area: 179225.36 Å2
Buried surface area: 77106.32 Å2
Dissociation area: 13,825.66 Å2
Dissociation energy (ΔGdiss): -3.69 kcal/mol
Dissociation entropy (TΔSdiss): 123.36 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-274016

Macromolecules

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
Chains: B1, B2, B3, B4, B5
Length: 340 amino acids
Theoretical weight: 37.42 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P62873 (Residues: 1-340; Coverage: 100%)
Gene name: GNB1
Pfam: WD domain, G-beta repeat
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 in PDB entry 8u83, assembly 1, front view.
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 in PDB entry 8u83, assembly 1, side view.
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 in PDB entry 8u83, assembly 1, top view.
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Cullin-3
Chains: C1, C2, C3, C4, C5
Length: 381 amino acids
Theoretical weight: 44.54 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q13618 (Residues: 1-381; Coverage: 50%)
Gene names: CUL3, KIAA0617
Pfam: Cullin family
Cullin-3 in PDB entry 8u83, assembly 1, front view.
Cullin-3 in PDB entry 8u83, assembly 1, side view.
Cullin-3 in PDB entry 8u83, assembly 1, top view.
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Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
Chains: G1, G2, G3, G4, G5
Length: 71 amino acids
Theoretical weight: 7.85 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P59768 (Residues: 1-71; Coverage: 100%)
Gene name: GNG2
Pfam: GGL domain
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 in PDB entry 8u83, assembly 1, front view.
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 in PDB entry 8u83, assembly 1, side view.
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 in PDB entry 8u83, assembly 1, top view.
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BTB/POZ domain-containing protein KCTD5
Chains: K1, K2, K3, K4, K5
Length: 234 amino acids
Theoretical weight: 26.13 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9NXV2 (Residues: 1-234; Coverage: 100%)
Gene name: KCTD5
Pfam: BTB/POZ domain
BTB/POZ domain-containing protein KCTD5 in PDB entry 8u83, assembly 1, front view.
BTB/POZ domain-containing protein KCTD5 in PDB entry 8u83, assembly 1, side view.
BTB/POZ domain-containing protein KCTD5 in PDB entry 8u83, assembly 1, top view.
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