› 8ubr

Electron Microscopy
2.7Å resolution

Complex of the phosphorylated human cystic fibrosis transmembrane conductance regulator (CFTR) with CFTRinh-172 and ATP/Mg

Released:
DOI: 10.2210/pdb8ubr/pdb
PDB entry 8ubr coloured by chain, front view.
PDB entry 8ubr coloured by chain, side view.
PDB entry 8ubr coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis for CFTR inhibition by CFTRinh-172.
Young PG, Levring J, Fiedorczuk K, Blanchard SC, Chen J
OpenAccess logo Proc Natl Acad Sci U S A 121 e2316675121 (2024)
PMID: 38422021
Related structures: EMD-42101

Function and Biology Details

Reaction catalysed: 
ATP + H(2)O + closed Cl(-) channel = ADP + phosphate + open Cl(-) channel
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-146638 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cystic fibrosis transmembrane conductance regulator Chain: A
Molecule details ›
Chain: A
Length: 1480 amino acids
Theoretical weight: 168.33 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P13569 (Residues: 1-1480; Coverage: 100%)
Gene names: ABCC7, CFTR
Sequence domains:

Ligands and Environments

5 bound ligands:
Ligand MG 2 x MG
Ligand ATP 2 x ATP
Ligand LBN 2 x LBN
Ligand CLR 2 x CLR
Ligand WG5 1 x WG5
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.7Å
Relevant EMDB volumes: EMD-42101
Expression system: Homo sapiens

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