EC 5.6.1.6: Channel-conductance-controlling ATPase
Reaction catalysed:
ATP + H(2)O + closed Cl(-) channel = ADP + phosphate + open Cl(-) channel
Systematic name:
ATP phosphohydrolase (channel-conductance-controlling)
Alternative Name(s):
- CFTR
- Cystic-fibrosis membrane-conductance-regulating protein
GO terms
Biochemical function:
- ABC-type transporter activity
- Sec61 translocon complex binding
- 14-3-3 protein binding
- protein-folding chaperone binding
- ATPase-coupled inorganic anion transmembrane transporter activity
- ATPase-coupled transmembrane transporter activity
- PDZ domain binding
- enzyme binding
- chloride channel inhibitor activity
- chloride channel regulator activity
- ATP hydrolysis activity
- isomerase activity
- chloride transmembrane transporter activity
- bicarbonate transmembrane transporter activity
- ATP binding
- protein binding
- intracellularly ATP-gated chloride channel activity
- chloride channel activity
Biological process:
- cellular response to forskolin
- positive regulation of voltage-gated chloride channel activity
- chloride transmembrane transport
- positive regulation of cyclic nucleotide-gated ion channel activity
- amelogenesis
- cellular response to cAMP
- positive regulation of enamel mineralization
- membrane hyperpolarization
- transmembrane transport
- establishment of localization in cell
- intracellular pH elevation
- multicellular organismal-level water homeostasis
- sperm capacitation
- positive regulation of exocytosis
- positive regulation of insulin secretion involved in cellular response to glucose stimulus
- transepithelial water transport
- response to endoplasmic reticulum stress
- monoatomic ion transmembrane transport
- cholesterol transport
- bicarbonate transport
- vesicle docking involved in exocytosis
- chloride transport
- monoatomic ion transport
- cholesterol biosynthetic process
Cellular component:
- recycling endosome membrane
- recycling endosome
- chloride channel complex
- protein-containing complex
- early endosome membrane
- clathrin-coated endocytic vesicle membrane
- Golgi-associated vesicle membrane
- apical plasma membrane
- membrane
- endosome membrane
- cell surface
- plasma membrane
- cytosol
- endoplasmic reticulum membrane
- endoplasmic reticulum
- early endosome
- endosome
- lysosomal membrane
- cytoplasm
- nucleus
Protein families (Pfam)
