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SARS-CoV-2 Nsp15 bound to poly(A/U) RNA, consensus form

Electron Microscopy
2.67Å resolution
PDB entry 8ud3 coloured by chain, front view.
PDB entry 8ud3 coloured by chain, side view.
PDB entry 8ud3 coloured by chain, top view.
Source organism: Severe acute respiratory syndrome coronavirus 2
Assembly composition:
hetero octamer (preferred)
Entry contents: 1 distinct polypeptide molecule
2 distinct RNA molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: SARS-CoV-2 NSP15 complex and RNA
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Multimeric state: hetero octamer
Accessible surface area: 84731.6 Å2
Buried surface area: 21065.47 Å2
Dissociation area: 1,024.13 Å2
Dissociation energy (ΔGdiss): 12.92 kcal/mol
Dissociation entropy (TΔSdiss): 11.49 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-273115

Macromolecules

Uridylate-specific endoribonuclease nsp15
Chains: A, B, C, D, E, F
Length: 359 amino acids
Theoretical weight: 40.21 KDa
Source organism: Severe acute respiratory syndrome coronavirus 2
Expression system: Escherichia coli
UniProt:
  • Canonical: P0DTD1 (Residues: 6453-6798; Coverage: 5%)
Gene names: 1a-1b, rep
Pfam:
Uridylate-specific endoribonuclease nsp15 in PDB entry 8ud3, assembly 1, front view.
Uridylate-specific endoribonuclease nsp15 in PDB entry 8ud3, assembly 1, side view.
Uridylate-specific endoribonuclease nsp15 in PDB entry 8ud3, assembly 1, top view.
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RNA chain G
Name: RNA (35-MER)
Representative chains: G
Source organism: Severe acute respiratory syndrome coronavirus 2 [2697049]
Expression system: Not provided
Length: 35 nucleotides
Theoretical weight: 10.84 KDa
RNA (35-MER) in PDB entry 8ud3, assembly 1, front view.
RNA (35-MER) in PDB entry 8ud3, assembly 1, side view.
RNA (35-MER) in PDB entry 8ud3, assembly 1, top view.
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RNA chain H
Name: RNA (35-MER)
Representative chains: H
Source organism: Severe acute respiratory syndrome coronavirus 2 [2697049]
Expression system: Not provided
Length: 35 nucleotides
Theoretical weight: 11.4 KDa
RNA (35-MER) in PDB entry 8ud3, assembly 1, front view.
RNA (35-MER) in PDB entry 8ud3, assembly 1, side view.
RNA (35-MER) in PDB entry 8ud3, assembly 1, top view.
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