Structure analysis

SARS-CoV-2 Nsp15 bound to poly(A/U) RNA, state 2

Electron Microscopy
3.13Å resolution
Assembly composition:
hetero octamer (preferred)
Entry contents: 1 distinct polypeptide molecule
2 distinct RNA molecules

Assemblies

Assembly 1 (preferred)
Download    3D Visualisation
Multimeric state: hetero octamer
Accessible surface area: 87617.23 Å2
Buried surface area: 22723.58 Å2
Dissociation area: 1,388.15 Å2
Dissociation energy (ΔGdiss): 19.43 kcal/mol
Dissociation entropy (TΔSdiss): 12.7 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-243438

Macromolecules

Chains: A, B, C, D, E, F
Length: 359 amino acids
Theoretical weight: 40.21 KDa
Source organism: Severe acute respiratory syndrome coronavirus 2
Expression system: Escherichia coli
UniProt:
  • Canonical: P0DTD1 (Residues: 6453-6798; Coverage: 5%)
Gene names: 1a-1b, rep
Pfam:

Search similar proteins

Name: RNA (35-MER)
Representative chains: G
Source organism: Severe acute respiratory syndrome coronavirus 2 [2697049]
Expression system: Not provided
Length: 35 nucleotides
Theoretical weight: 10.84 KDa

Search similar RNA

Name: RNA (35-MER)
Representative chains: H
Source organism: Severe acute respiratory syndrome coronavirus 2 [2697049]
Expression system: Not provided
Length: 35 nucleotides
Theoretical weight: 11.4 KDa

Search similar RNA