Function and Biology

The rotavirus VP5*/VP8* conformational transition permeabilizes membranes to Ca2+ (class 5 reconstruction)

Source organism: Simian rotavirus A strain RRV
Biochemical function: not assigned
Biological process: symbiont entry into host cell via permeabilization of host membrane
Cellular component: viral capsid

Sequence families

Pfam Protein families (Pfam)
PF00434
Domain description: Glycoprotein VP7
Occurring in:
  1. Outer capsid glycoprotein VP7
The deposited structure of PDB entry 8uk2 contains 18 copies of Pfam domain PF00434 (Glycoprotein VP7) in Outer capsid glycoprotein VP7. Showing 1 copy in chain H [auth j].

PF17478
Domain description: Rotavirus VP4 helical domain
Occurring in:
  1. Outer capsid protein VP4
The deposited structure of PDB entry 8uk2 contains 3 copies of Pfam domain PF17478 (Rotavirus VP4 helical domain) in Outer capsid protein VP4. Showing 1 copy in chain A [auth 1].

PF17477
Domain description: Rotavirus VP4 membrane interaction domain
Occurring in:
  1. Outer capsid protein VP4
The deposited structure of PDB entry 8uk2 contains 3 copies of Pfam domain PF17477 (Rotavirus VP4 membrane interaction domain) in Outer capsid protein VP4. Showing 1 copy in chain A [auth 1].

PF00426
Domain description: Outer Capsid protein VP4 (Hemagglutinin) Concanavalin-like domain
Occurring in:
  1. Outer capsid protein VP4
The deposited structure of PDB entry 8uk2 contains 3 copies of Pfam domain PF00426 (Outer Capsid protein VP4 (Hemagglutinin) Concanavalin-like domain) in Outer capsid protein VP4. Showing 1 copy in chain A [auth 1] (this domain is out of the observed residue ranges!).