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The rotavirus VP5*/VP8* conformational transition permeabilizes membranes to Ca2+ (class 5 reconstruction)

Electron Microscopy
8Å resolution
PDB entry 8uk2 coloured by chain, front view.
PDB entry 8uk2 coloured by chain, side view.
PDB entry 8uk2 coloured by chain, top view.
Source organism: Simian rotavirus A strain RRV
Assembly composition:
hetero 21-mer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Outer capsid protein VP8* and Outer capsid glycoprotein VP7
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Multimeric state: hetero 21-mer
Accessible surface area: 240453.09 Å2
Buried surface area: 83937.7 Å2
Dissociation area: 1,990.93 Å2
Dissociation energy (ΔGdiss): 6.59 kcal/mol
Dissociation entropy (TΔSdiss): 16.61 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-245770

Macromolecules

Outer capsid protein VP4
Chains: 1, 2, 3
Length: 776 amino acids
Theoretical weight: 86.66 KDa
Source organism: Simian rotavirus A strain RRV
Expression system: Chlorocebus aethiops
UniProt:
  • Canonical: P12473 (Residues: 1-776; Coverage: 100%)
Pfam:
Outer capsid protein VP4 in PDB entry 8uk2, assembly 1, front view.
Outer capsid protein VP4 in PDB entry 8uk2, assembly 1, side view.
Outer capsid protein VP4 in PDB entry 8uk2, assembly 1, top view.
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Outer capsid glycoprotein VP7
Chains: a, b, c, d, e, f, g, h, i, j, k, l, m, n, o, p, q, r
Length: 326 amino acids
Theoretical weight: 37.14 KDa
Source organism: Simian rotavirus A strain RRV
Expression system: Chlorocebus aethiops
UniProt:
  • Canonical: P12476 (Residues: 1-326; Coverage: 100%)
Pfam: Glycoprotein VP7
Outer capsid glycoprotein VP7 in PDB entry 8uk2, assembly 1, front view.
Outer capsid glycoprotein VP7 in PDB entry 8uk2, assembly 1, side view.
Outer capsid glycoprotein VP7 in PDB entry 8uk2, assembly 1, top view.
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