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Crystal structure of human NUAK1-MARK3 kinase domain chimera bound with small molecule inhibitor #65

X-ray diffraction
1.8Å resolution
PDB entry 8uoi coloured by chain, front view.
PDB entry 8uoi coloured by chain, side view.
PDB entry 8uoi coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: MAP/microtubule affinity-regulating kinase 3
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Multimeric state: monomeric
Accessible surface area: 16057.89 Å2
Buried surface area: 1008.07 Å2
Dissociation area: 108.62 Å2
Dissociation energy (ΔGdiss): -2.57 kcal/mol
Dissociation entropy (TΔSdiss): -0.37 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-151007

Macromolecules

MAP/microtubule affinity-regulating kinase 3
Chain: A
Length: 328 amino acids
Theoretical weight: 37.9 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P27448 (Residues: 48-370; Coverage: 43%)
Gene names: CTAK1, EMK2, MARK3
Pfam:
MAP/microtubule affinity-regulating kinase 3 in PDB entry 8uoi, assembly 1, front view.
MAP/microtubule affinity-regulating kinase 3 in PDB entry 8uoi, assembly 1, side view.
MAP/microtubule affinity-regulating kinase 3 in PDB entry 8uoi, assembly 1, top view.
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