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Human LINE-1 retrotransposon ORF2 protein engaged with template RNA in elongation state

Source organisms:
Biochemical function: metal ion binding
Biological process: nucleic acid metabolic process
Cellular component: not assigned

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EC 2.7.7.49: RNA-directed DNA polymerase

Reaction catalysed:
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1)
Systematic name:
Deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (RNA-directed)
Alternative Name(s):
  • DNA nucleotidyltransferase (RNA-directed)
  • RNA revertase
  • RNA-dependent DNA polymerase
  • RNA-dependent deoxyribonucleate nucleotidyltransferase
  • RNA-instructed DNA polymerase
  • RT
  • Reverse transcriptase
  • Revertase

GO terms

Sequence families

Pfam Protein families (Pfam)
PF00078
Domain description: Reverse transcriptase (RNA-dependent DNA polymerase)
Occurring in:
  1. LINE-1 retrotransposable element ORF2 protein
The deposited structure of PDB entry 8uw3 contains 1 copy of Pfam domain PF00078 (Reverse transcriptase (RNA-dependent DNA polymerase)) in LINE-1 retrotransposable element ORF2 protein. Showing 1 copy in chain A.

PF03372
Domain description: Endonuclease/Exonuclease/phosphatase family
Occurring in:
  1. LINE-1 retrotransposable element ORF2 protein
The deposited structure of PDB entry 8uw3 contains 1 copy of Pfam domain PF03372 (Endonuclease/Exonuclease/phosphatase family) in LINE-1 retrotransposable element ORF2 protein. Showing 1 copy in chain A.

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