› › Function and Biology

Methylenetetrahydrofolate reductase from Chaetomium thermophilum DSM 1495, AdoMet-bound, Inhibited (T) State

Source organism: Chaetomium thermophilum var. thermophilum DSM 1495
Biochemical function: FAD binding
Biological process: tetrahydrofolate interconversion
Cellular component: cytosol

Quick links

EC 1.5.1.20: Methylenetetrahydrofolate reductase (NAD(P)H)

Reaction catalysed:
5-methyltetrahydrofolate + NAD(P)(+) = 5,10-methylenetetrahydrofolate + NAD(P)H
Systematic name:
5-methyltetrahydrofolate:NAD(P)(+) oxidoreductase
Alternative Name(s):
  • MTHFR

GO terms

Sequence families

Pfam Protein families (Pfam)
PF21895
Domain description: MTHFR, SAM-binding regulatory domain
Occurring in:
  1. MTHFR SAM-binding regulatory domain-containing protein
The deposited structure of PDB entry 8uy2 contains 4 copies of Pfam domain PF21895 (MTHFR, SAM-binding regulatory domain) in Methylenetetrahydrofolate reductase-like protein. Showing 1 copy in chain D.

PF02219
Domain description: Methylenetetrahydrofolate reductase
Occurring in:
  1. MTHFR SAM-binding regulatory domain-containing protein
The deposited structure of PDB entry 8uy2 contains 4 copies of Pfam domain PF02219 (Methylenetetrahydrofolate reductase) in Methylenetetrahydrofolate reductase-like protein. Showing 1 copy in chain D.

Quick links