› 8v38

Electron Microscopy
3.5Å resolution

Structure of the human systemic RNAi defective transmembrane protein 1 (hSIDT1)

Released:
DOI: 10.2210/pdb8v38/pdb
PDB entry 8v38 coloured by chain, front view.
PDB entry 8v38 coloured by chain, side view.
PDB entry 8v38 coloured by chain, top view.
Source organisms:
Primary publication:
Structure of the human systemic RNAi defective transmembrane protein 1 (hSIDT1) reveals the conformational flexibility of its lipid binding domain.
Navratna V, Kumar A, Rana JK, Mosalaganti S
OpenAccess logo bioRxiv (2024)
PMID: 38187772
Related structures: EMD-42943

Function and Biology Details

Reactions catalysed: 
(1a) S-adenosyl-L-methionine + G(5')pppAACA-[mRNA] = S-adenosyl-L-homocysteine + G(5')pppAmACA-[mRNA]
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1)
(1a) (5')pppAACA-[mRNA] + (protein L)-L-histidine = diphosphate + (protein L)-L-histidyl-(5')phosphonato-AACA-[mRNA] + H(2)O
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-246191 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
RNA-directed RNA polymerase L; SID1 transmembrane family member 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 1097 amino acids
Theoretical weight: 124.1 KDa
Source organisms: Expression system: Homo sapiens
UniProt:
  • Canonical: Q9NXL6 (Residues: 1-827; Coverage: 100%)
  • Canonical: A0A5P9VSM8 (Residues: 1740-1980; Coverage: 10%)
Gene name: SIDT1
Sequence domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.5Å
Relevant EMDB volumes: EMD-42943
Expression system: Homo sapiens

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