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Structure of the human systemic RNAi defective transmembrane protein 1 (hSIDT1)

Electron Microscopy
3.5Å resolution
PDB entry 8v38 coloured by chain, front view.
PDB entry 8v38 coloured by chain, side view.
PDB entry 8v38 coloured by chain, top view.
Source organisms:
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: RNA-directed RNA polymerase L, SID1 transmembrane family member 1
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Multimeric state: homo dimer
Accessible surface area: 66435.35 Å2
Buried surface area: 3614.96 Å2
Dissociation area: 1,807.48 Å2
Dissociation energy (ΔGdiss): 18.29 kcal/mol
Dissociation entropy (TΔSdiss): 15.68 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-246191

Macromolecules

RNA-directed RNA polymerase L; SID1 transmembrane family member 1
Chains: A, B
Length: 1097 amino acids
Theoretical weight: 124.1 KDa
Source organisms: Expression system: Homo sapiens
UniProt:
  • Canonical: Q9NXL6 (Residues: 1-827; Coverage: 100%)
  • Canonical: A0A5P9VSM8 (Residues: 1740-1980; Coverage: 10%)
    • nullnull
Gene name: SIDT1
Pfam:
RNA-directed RNA polymerase L in PDB entry 8v38, assembly 1, front view.
RNA-directed RNA polymerase L in PDB entry 8v38, assembly 1, side view.
RNA-directed RNA polymerase L in PDB entry 8v38, assembly 1, top view.
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