› 8vsp

Electron Microscopy
3.12Å resolution

Cryo-EM structure of human invariant chain in complex with HLA-DQ

Released:
DOI: 10.2210/pdb8vsp/pdb
PDB entry 8vsp coloured by chain, front view.
PDB entry 8vsp coloured by chain, side view.
PDB entry 8vsp coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural insights into human MHC-II association with invariant chain.
Wang N, Waghray D, Caveney NA, Jude KM, Garcia KC
Proc Natl Acad Sci U S A 121 e2403031121 (2024)
PMID: 38687785
Related structures: EMD-43501

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero nonamer (preferred)
PDBe Complex ID:
PDB-CPX-244071 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
HLA class II histocompatibility antigen, DQ alpha 1 chain Chains: A, D, G
Molecule details ›
Chains: A, D, G
Length: 288 amino acids
Theoretical weight: 31.6 KDa
Source organism: Homo sapiens
Expression system: Mammalia
UniProt:
  • Canonical: P01909 (Residues: 1-254; Coverage: 100%)
Gene name: HLA-DQA1
Sequence domains:
HLA class II histocompatibility antigen, DQ beta 1 chain Chains: B, E, H
Molecule details ›
Chains: B, E, H
Length: 295 amino acids
Theoretical weight: 33.8 KDa
Source organism: Homo sapiens
Expression system: Mammalia
UniProt:
  • Canonical: P01920 (Residues: 1-261; Coverage: 100%)
Gene names: HLA-DQB, HLA-DQB1
Sequence domains:
HLA class II histocompatibility antigen gamma chain Chains: C, F, I
Molecule details ›
Chains: C, F, I
Length: 308 amino acids
Theoretical weight: 34.9 KDa
Source organism: Homo sapiens
Expression system: Mammalia
UniProt:
  • Canonical: P04233 (Residues: 2-296; Coverage: 100%)
Gene names: CD74, DHLAG
Sequence domains:

Ligands and Environments

1 bound ligand:
Ligand NAG 3 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.12Å
Relevant EMDB volumes: EMD-43501
Expression system: Mammalia

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