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Cryo-EM structure of human invariant chain in complex with HLA-DQ

Electron Microscopy
3.12Å resolution
PDB entry 8vsp coloured by chain, front view.
PDB entry 8vsp coloured by chain, side view.
PDB entry 8vsp coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero nonamer (preferred)
Entry contents: 3 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero nonamer
Accessible surface area: 72513.53 Å2
Buried surface area: 37468.21 Å2
Dissociation area: 5,372.56 Å2
Dissociation energy (ΔGdiss): 54.35 kcal/mol
Dissociation entropy (TΔSdiss): 31.44 kcal/mol
Symmetry number: 3
PDBe Complex ID: PDB-CPX-272080

Macromolecules

HLA class II histocompatibility antigen, DQ alpha 1 chain
Chains: A, D, G
Length: 288 amino acids
Theoretical weight: 31.6 KDa
Source organism: Homo sapiens
Expression system: Mammalia
UniProt:
  • Canonical: P01909 (Residues: 1-254; Coverage: 100%)
Gene name: HLA-DQA1
Pfam:
HLA class II histocompatibility antigen, DQ alpha 1 chain in PDB entry 8vsp, assembly 1, front view.
HLA class II histocompatibility antigen, DQ alpha 1 chain in PDB entry 8vsp, assembly 1, side view.
HLA class II histocompatibility antigen, DQ alpha 1 chain in PDB entry 8vsp, assembly 1, top view.
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HLA class II histocompatibility antigen, DQ beta 1 chain
Chains: B, E, H
Length: 295 amino acids
Theoretical weight: 33.8 KDa
Source organism: Homo sapiens
Expression system: Mammalia
UniProt:
  • Canonical: P01920 (Residues: 1-261; Coverage: 100%)
Gene names: HLA-DQB, HLA-DQB1
Pfam:
HLA class II histocompatibility antigen, DQ beta 1 chain in PDB entry 8vsp, assembly 1, front view.
HLA class II histocompatibility antigen, DQ beta 1 chain in PDB entry 8vsp, assembly 1, side view.
HLA class II histocompatibility antigen, DQ beta 1 chain in PDB entry 8vsp, assembly 1, top view.
Molecule details ›

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HLA class II histocompatibility antigen gamma chain
Chains: C, F, I
Length: 308 amino acids
Theoretical weight: 34.9 KDa
Source organism: Homo sapiens
Expression system: Mammalia
UniProt:
  • Canonical: P04233 (Residues: 2-296; Coverage: 100%)
Gene names: CD74, DHLAG
Pfam:
HLA class II histocompatibility antigen gamma chain in PDB entry 8vsp, assembly 1, front view.
HLA class II histocompatibility antigen gamma chain in PDB entry 8vsp, assembly 1, side view.
HLA class II histocompatibility antigen gamma chain in PDB entry 8vsp, assembly 1, top view.
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