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Structure of FabS1CE3-EPR-1, an elbow-locked high affinity antibody for the erythropoeitin receptor (orthorhombic form)

X-ray diffraction
1.96Å resolution
PDB entry 8vtr coloured by chain, front view.
PDB entry 8vtr coloured by chain, side view.
PDB entry 8vtr coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: IG-heavy chain and IG-light kappa chain
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Multimeric state: hetero dimer
Accessible surface area: 21106.84 Å2
Buried surface area: 3239.98 Å2
Dissociation area: 872.39 Å2
Dissociation energy (ΔGdiss): 2.08 kcal/mol
Dissociation entropy (TΔSdiss): 12.56 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-247504

Macromolecules

S1CE3 VARIANT OF FAB-EPR-1 heavy chain
Chain: A
Length: 224 amino acids
Theoretical weight: 24.14 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
S1CE3 VARIANT OF FAB-EPR-1 heavy chain in PDB entry 8vtr, assembly 1, front view.
S1CE3 VARIANT OF FAB-EPR-1 heavy chain in PDB entry 8vtr, assembly 1, side view.
S1CE3 VARIANT OF FAB-EPR-1 heavy chain in PDB entry 8vtr, assembly 1, top view.
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S1CE3 VARIANT OF FAB-EPR-1 light chain
Chain: G
Length: 212 amino acids
Theoretical weight: 23.05 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
S1CE3 VARIANT OF FAB-EPR-1 light chain in PDB entry 8vtr, assembly 1, front view.
S1CE3 VARIANT OF FAB-EPR-1 light chain in PDB entry 8vtr, assembly 1, side view.
S1CE3 VARIANT OF FAB-EPR-1 light chain in PDB entry 8vtr, assembly 1, top view.
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