› 8vu5

Electron Microscopy
3.39Å resolution

Cryo-EM structure of MPL bound to TPO

Released:
DOI: 10.2210/pdb8vu5/pdb
PDB entry 8vu5 coloured by chain, front view.
PDB entry 8vu5 coloured by chain, side view.
PDB entry 8vu5 coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Structural basis of MPL activation by thrombopoietin
Mafi A, Bratkowski M, Geng J, Brito AA, Sridar J, Hu D, Darcy AT, Nanavati D, Brown NJ, Rathinaswamy MK, Kutskova Y, Eaton D, Hao Q, Paddock M
Blood Vessels, Thrombosis & Hemostasis 1 100018- (2024)
Related structures: EMD-43526

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-273688 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Thrombopoietin Chain: A
Molecule details ›
Chain: A
Length: 170 amino acids
Theoretical weight: 18.37 KDa
Source organism: Mus musculus
Expression system: Homo sapiens
UniProt:
  • Canonical: P40226 (Residues: 22-184; Coverage: 49%)
Gene name: Thpo
Sequence domains: Erythropoietin/thrombopoietin
Thrombopoietin receptor Chains: B, C
Molecule details ›
Chains: B, C
Length: 463 amino acids
Theoretical weight: 52.03 KDa
Source organism: Mus musculus
Expression system: Homo sapiens
UniProt:
  • Canonical: Q08351 (Residues: 26-482; Coverage: 76%)
Gene names: Mpl, Tpor
Sequence domains: Erythropoietin receptor, ligand binding

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.39Å
Relevant EMDB volumes: EMD-43526
Expression system: Homo sapiens

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