› 8vue

Electron Microscopy
3.59Å resolution

L5A7 Fab bound to Indonesia2005 Hemagglutinin

Released:
DOI: 10.2210/pdb8vue/pdb
PDB entry 8vue coloured by chain, front view.
PDB entry 8vue coloured by chain, side view.
PDB entry 8vue coloured by chain, top view.
Source organisms:
Primary publication:
Anti-idiotype isolation of a broad and potent influenza A virus-neutralizing human antibody.
Olia AS, Prabhakaran M, Harris DR, Cheung CS, Gillespie RA, Gorman J, Hoover A, Morano NC, Ourahmane A, Srikanth A, Wang S, Wu W, Zhou T, Andrews SF, Kanekiyo M, Shapiro L, McDermott AB, Kwong PD
Front Immunol 15 1399960 (2024)
PMID: 38873606
Related structures: EMD-43529

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dodecamer (preferred)
PDBe Complex ID:
PDB-CPX-244465 (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (4 distinct):
Hemagglutinin Chains: A, C, E
Molecule details ›
Chains: A, C, E
Length: 326 amino acids
Theoretical weight: 36.79 KDa
Source organism: Influenza A virus
Expression system: Homo sapiens
UniProt:
  • Canonical: A8HWY8 (Residues: 17-341; Coverage: 57%)
Gene name: HA
Sequence domains: Haemagglutinin
Hemagglutinin HA2 chain Chains: B, D, F
Molecule details ›
Chains: B, D, F
Length: 169 amino acids
Theoretical weight: 19.64 KDa
Source organism: Influenza A virus
Expression system: Homo sapiens
UniProt:
  • Canonical: C5MRF2 (Residues: 342-510; Coverage: 30%)
Gene name: HA
Sequence domains: Haemagglutinin
L5A7 Fab Heavy Chain Chains: G, I, K
Molecule details ›
Chains: G, I, K
Length: 230 amino acids
Theoretical weight: 24.64 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
L5A7 Fab Light Chain Chains: H, J, L
Molecule details ›
Chains: H, J, L
Length: 210 amino acids
Theoretical weight: 22.72 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens

Ligands and Environments

1 bound ligand:
Ligand NAG 3 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.59Å
Relevant EMDB volumes: EMD-43529
Expression system: Homo sapiens

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