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L5A7 Fab bound to Indonesia2005 Hemagglutinin

Electron Microscopy
3.59Å resolution
PDB entry 8vue coloured by chain, front view.
PDB entry 8vue coloured by chain, side view.
PDB entry 8vue coloured by chain, top view.
Source organisms:
Assembly composition:
hetero dodecamer (preferred)
Entry contents: 4 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero dodecamer
Accessible surface area: 114145.52 Å2
Buried surface area: 43293.88 Å2
Dissociation area: 3,064.12 Å2
Dissociation energy (ΔGdiss): -9.16 kcal/mol
Dissociation entropy (TΔSdiss): 45.33 kcal/mol
Symmetry number: 3
PDBe Complex ID: PDB-CPX-246527

Macromolecules

Hemagglutinin
Chains: A, C, E
Length: 326 amino acids
Theoretical weight: 36.79 KDa
Source organism: Influenza A virus
Expression system: Homo sapiens
UniProt:
  • Canonical: A8HWY8 (Residues: 17-341; Coverage: 57%)
Gene name: HA
Pfam: Haemagglutinin
Hemagglutinin in PDB entry 8vue, assembly 1, front view.
Hemagglutinin in PDB entry 8vue, assembly 1, side view.
Hemagglutinin in PDB entry 8vue, assembly 1, top view.
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Hemagglutinin HA2 chain
Chains: B, D, F
Length: 169 amino acids
Theoretical weight: 19.64 KDa
Source organism: Influenza A virus
Expression system: Homo sapiens
UniProt:
  • Canonical: C5MRF2 (Residues: 342-510; Coverage: 30%)
Gene name: HA
Pfam: Haemagglutinin
Hemagglutinin HA2 chain in PDB entry 8vue, assembly 1, front view.
Hemagglutinin HA2 chain in PDB entry 8vue, assembly 1, side view.
Hemagglutinin HA2 chain in PDB entry 8vue, assembly 1, top view.
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L5A7 Fab Heavy Chain
Chains: G, I, K
Length: 230 amino acids
Theoretical weight: 24.64 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
L5A7 Fab Heavy Chain in PDB entry 8vue, assembly 1, front view.
L5A7 Fab Heavy Chain in PDB entry 8vue, assembly 1, side view.
L5A7 Fab Heavy Chain in PDB entry 8vue, assembly 1, top view.
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L5A7 Fab Light Chain
Chains: H, J, L
Length: 210 amino acids
Theoretical weight: 22.72 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
L5A7 Fab Light Chain in PDB entry 8vue, assembly 1, front view.
L5A7 Fab Light Chain in PDB entry 8vue, assembly 1, side view.
L5A7 Fab Light Chain in PDB entry 8vue, assembly 1, top view.
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