› 8vuh

Electron Microscopy
4.42Å resolution

Human GluN1-2A IgG 003-102 splayed conformation

Released:
DOI: 10.2210/pdb8vuh/pdb
PDB entry 8vuh coloured by chain, front view.
PDB entry 8vuh coloured by chain, side view.
PDB entry 8vuh coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural and functional mechanisms of anti-NMDAR autoimmune encephalitis.
Michalski K, Abdulla T, Kleeman S, Schmidl L, Gómez R, Simorowski N, Vallese F, Prüss H, Heckmann M, Geis C, Furukawa H
Nat Struct Mol Biol (2024)
PMID: 39227719
Related structures: EMD-43530

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero octamer (preferred)
PDBe Complex ID:
PDB-CPX-274440 (preferred)
Entry contents:
5 distinct polypeptide molecules
Macromolecules (5 distinct):
Glutamate receptor ionotropic, NMDA 1 Chain: A
Molecule details ›
Chain: A
Length: 815 amino acids
Theoretical weight: 91.68 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q05586 (Residues: 27-841; Coverage: 89%)
Gene names: GRIN1, NMDAR1
Sequence domains:
Glutamate receptor ionotropic, NMDA 2A Chains: B, D
Molecule details ›
Chains: B, D
Length: 808 amino acids
Theoretical weight: 90.68 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q12879 (Residues: 34-841; Coverage: 56%)
Gene names: GRIN2A, NMDAR2A
Sequence domains:
Glutamate receptor ionotropic, NMDA 1 Chain: C
Molecule details ›
Chain: C
Length: 816 amino acids
Theoretical weight: 91.84 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q05586 (Residues: 26-841; Coverage: 89%)
Gene names: GRIN1, NMDAR1
Sequence domains:
003-102 Heavy Chains: H, I
Molecule details ›
Chains: H, I
Length: 117 amino acids
Theoretical weight: 12.68 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
003-102 Light Chains: L, M
Molecule details ›
Chains: L, M
Length: 109 amino acids
Theoretical weight: 11.68 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 4.42Å
Relevant EMDB volumes: EMD-43530
Expression systems:
  • Spodoptera frugiperda
  • Homo sapiens

Quick links