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Human GluN1-2A IgG 003-102 splayed conformation

Electron Microscopy
4.42Å resolution
PDB entry 8vuh coloured by chain, front view.
PDB entry 8vuh coloured by chain, side view.
PDB entry 8vuh coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero octamer (preferred)
Entry contents: 5 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero octamer
Accessible surface area: 170765.8 Å2
Buried surface area: 19921.7 Å2
Dissociation area: 1,347.39 Å2
Dissociation energy (ΔGdiss): -18.77 kcal/mol
Dissociation entropy (TΔSdiss): 27.32 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-274440

Macromolecules

Glutamate receptor ionotropic, NMDA 1
Chain: A
Length: 815 amino acids
Theoretical weight: 91.68 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q05586 (Residues: 27-841; Coverage: 89%)
Gene names: GRIN1, NMDAR1
Pfam:
Glutamate receptor ionotropic, NMDA 1 in PDB entry 8vuh, assembly 1, front view.
Glutamate receptor ionotropic, NMDA 1 in PDB entry 8vuh, assembly 1, side view.
Glutamate receptor ionotropic, NMDA 1 in PDB entry 8vuh, assembly 1, top view.
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Glutamate receptor ionotropic, NMDA 2A
Chains: B, D
Length: 808 amino acids
Theoretical weight: 90.68 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q12879 (Residues: 34-841; Coverage: 56%)
Gene names: GRIN2A, NMDAR2A
Pfam:
Glutamate receptor ionotropic, NMDA 2A in PDB entry 8vuh, assembly 1, front view.
Glutamate receptor ionotropic, NMDA 2A in PDB entry 8vuh, assembly 1, side view.
Glutamate receptor ionotropic, NMDA 2A in PDB entry 8vuh, assembly 1, top view.
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Glutamate receptor ionotropic, NMDA 1
Chain: C
Length: 816 amino acids
Theoretical weight: 91.84 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q05586 (Residues: 26-841; Coverage: 89%)
Gene names: GRIN1, NMDAR1
Pfam:
Glutamate receptor ionotropic, NMDA 1 in PDB entry 8vuh, assembly 1, front view.
Glutamate receptor ionotropic, NMDA 1 in PDB entry 8vuh, assembly 1, side view.
Glutamate receptor ionotropic, NMDA 1 in PDB entry 8vuh, assembly 1, top view.
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003-102 Heavy
Chains: H, I
Length: 117 amino acids
Theoretical weight: 12.68 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
003-102 Heavy in PDB entry 8vuh, assembly 1, front view.
003-102 Heavy in PDB entry 8vuh, assembly 1, side view.
003-102 Heavy in PDB entry 8vuh, assembly 1, top view.
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003-102 Light
Chains: L, M
Length: 109 amino acids
Theoretical weight: 11.68 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
003-102 Light in PDB entry 8vuh, assembly 1, front view.
003-102 Light in PDB entry 8vuh, assembly 1, side view.
003-102 Light in PDB entry 8vuh, assembly 1, top view.
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