EC 3.4.21.42: Complement subcomponent C1s
Reaction catalysed:
Cleavage of Arg-|-Ala bond in complement component C4 to form C4a and C4b, and Lys(or Arg)-|-Lys bond in complement component C2 to form C2a and C2b: the 'classical' pathway C3 convertase.
Systematic name:
-
Alternative Name(s):
- Activated complement C1s
- C1 esterase
- C1s esterase
- Complement C1s
GO terms
Biochemical function:
- not assigned
Biological process:
- not assigned
Cellular component:
- not assigned
Protein families (Pfam)![The deposited structure of PDB entry 8w18 contains 2 copies of Pfam domain PF00084 (Sushi repeat (SCR repeat)) in Complement C1s subcomponent heavy chain. Showing 2 copies in chain C [auth A].](https://www.ebi.ac.uk/pdbe/static/entry/8w18_3_A_Pfam_PF00084_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>8w18</span> contains 2 copies of Pfam domain <span class='highlight'>PF00084 (Sushi repeat (SCR repeat))</span> in <span class='highlight'>Complement C1s subcomponent heavy chain</span>. Showing 2 copies in chain <span class='highlight'>C [auth A]</span>.")
![The deposited structure of PDB entry 8w18 contains 1 copy of Pfam domain PF00079 (Serpin (serine protease inhibitor)) in Plasma protease C1 inhibitor. Showing 1 copy in chain A [auth I].](https://www.ebi.ac.uk/pdbe/static/entry/8w18_1_I_Pfam_PF00079_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>8w18</span> contains 1 copy of Pfam domain <span class='highlight'>PF00079 (Serpin (serine protease inhibitor))</span> in <span class='highlight'>Plasma protease C1 inhibitor</span>. Showing 1 copy in chain <span class='highlight'>A [auth I]</span>.")
