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The crystal structure of the Michaelis-Menten complex of a C1s/C1-INH at 3.94 Angstroms

X-ray diffraction
3.94Å resolution
PDB entry 8w18 coloured by chain, front view.
PDB entry 8w18 coloured by chain, side view.
PDB entry 8w18 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero trimer (preferred)
Entry contents: 3 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Complement C1s subcomponent heavy chain and Plasma protease C1 inhibitor
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Multimeric state: hetero trimer
Accessible surface area: 35240.72 Å2
Buried surface area: 4536.16 Å2
Dissociation area: 1,337.8 Å2
Dissociation energy (ΔGdiss): 3.89 kcal/mol
Dissociation entropy (TΔSdiss): 13.85 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-246329

Macromolecules

Plasma protease C1 inhibitor
Chain: I
Length: 395 amino acids
Theoretical weight: 44 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P05155 (Residues: 111-500; Coverage: 82%)
Gene names: C1IN, C1NH, SERPING1
Pfam: Serpin (serine protease inhibitor)
Plasma protease C1 inhibitor in PDB entry 8w18, assembly 1, front view.
Plasma protease C1 inhibitor in PDB entry 8w18, assembly 1, side view.
Plasma protease C1 inhibitor in PDB entry 8w18, assembly 1, top view.
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Complement C1s subcomponent light chain
Chain: B
Length: 251 amino acids
Theoretical weight: 27.67 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P09871 (Residues: 438-688; Coverage: 37%)
Gene name: C1S
Pfam: Trypsin
Complement C1s subcomponent light chain in PDB entry 8w18, assembly 1, front view.
Complement C1s subcomponent light chain in PDB entry 8w18, assembly 1, side view.
Complement C1s subcomponent light chain in PDB entry 8w18, assembly 1, top view.
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Complement C1s subcomponent heavy chain
Chain: A
Length: 151 amino acids
Theoretical weight: 16.59 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P09871 (Residues: 292-437; Coverage: 22%)
Gene name: C1S
Pfam: Sushi repeat (SCR repeat)
Complement C1s subcomponent heavy chain in PDB entry 8w18, assembly 1, front view.
Complement C1s subcomponent heavy chain in PDB entry 8w18, assembly 1, side view.
Complement C1s subcomponent heavy chain in PDB entry 8w18, assembly 1, top view.
Molecule details ›

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