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Crystal structure of open conformation of human immunoglobulin Fc in presence of EndoSz

X-ray diffraction
2.18Å resolution
PDB entry 8w4m coloured by chain, front view.
PDB entry 8w4m coloured by chain, side view.
PDB entry 8w4m coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: IG-heavy chain
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Multimeric state: monomeric
Accessible surface area: 12313.97 Å2
Buried surface area: 3714.75 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-246605

Macromolecules

Immunoglobulin gamma-1 heavy chain
Chain: A
Length: 223 amino acids
Theoretical weight: 25.13 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P0DOX5 (Residues: 227-449; Coverage: 50%)
Pfam: Immunoglobulin C1-set domain
Immunoglobulin gamma-1 heavy chain in PDB entry 8w4m, assembly 1, front view.
Immunoglobulin gamma-1 heavy chain in PDB entry 8w4m, assembly 1, side view.
Immunoglobulin gamma-1 heavy chain in PDB entry 8w4m, assembly 1, top view.
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