EC 7.6.2.2: ABC-type xenobiotic transporter
Reaction catalysed:
ATP + H(2)O + xenobiotic(Side 1) = ADP + phosphate + xenobiotic(Side 2)
Systematic name:
ATP phosphohydrolase (ABC-type, xenobiotic-exporting)
Alternative Name(s):
- ATP phosphohydrolase (steroid-exporting)
- MDR protein
- Multidrug-resistance protein
- P-glycoprotein
- PDR protein
- Pleiotropic-drug-resistance protein
- Steroid-transporting ATPase
- Xenobiotic-transporting ATPase
GO terms
Biochemical function:
- carbohydrate derivative transmembrane transporter activity
- ABC-type transporter activity
- ATPase-coupled inorganic anion transmembrane transporter activity
- xenobiotic transmembrane transporter activity
- ATPase-coupled transmembrane transporter activity
- glutathione transmembrane transporter activity
- macromolecule transmembrane transporter activity
- efflux transmembrane transporter activity
- heme transmembrane transporter activity
- purine nucleotide transmembrane transporter activity
- ABC-type xenobiotic transporter activity
- organic anion transmembrane transporter activity
- ATP binding
Biological process:
- transport across blood-brain barrier
- export across plasma membrane
- folate transmembrane transport
- monoatomic anion transmembrane transport
- cGMP transport
- cAMP transport
- transmembrane transport
- xenobiotic transport
- heme transmembrane transport
- glutathione transmembrane transport
- hyaluronan biosynthetic process
- purine nucleotide transport
- xenobiotic transmembrane transport
- xenobiotic metabolic process
Protein families (Pfam)
