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CryoEM structure of ZIKV rsNS1

Electron Microscopy
3Å resolution
PDB entry 8wn8 coloured by chain, front view.
PDB entry 8wn8 coloured by chain, side view.
PDB entry 8wn8 coloured by chain, top view.
Source organism: Zika virus
Assembly composition:
homo tetramer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Serine protease subunit NS2B
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Multimeric state: homo tetramer
Accessible surface area: 62517.27 Å2
Buried surface area: 11157.21 Å2
Dissociation area: 1,139.75 Å2
Dissociation energy (ΔGdiss): 13.07 kcal/mol
Dissociation entropy (TΔSdiss): 14.8 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-174295

Macromolecules

Non-structural protein 1
Chains: B, C, D, E
Length: 361 amino acids
Theoretical weight: 41.25 KDa
Source organism: Zika virus
Expression system: Homo sapiens
UniProt:
  • Canonical: Q32ZE1 (Residues: 791-1143; Coverage: 10%)
Pfam: Flavivirus non-structural Protein NS1
Non-structural protein 1 in PDB entry 8wn8, assembly 1, front view.
Non-structural protein 1 in PDB entry 8wn8, assembly 1, side view.
Non-structural protein 1 in PDB entry 8wn8, assembly 1, top view.
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